Periodontitis is associated with preeclampsia in pregnant women
Periodontitis is associated with preeclampsia in pregnant women
复制标题
DOI：
10.1902/jop.2006.050020
复制
发表时间：
2006-02-01
影响因子：
4.3
通讯作者：
Botero, J. E.
中科院分区：
文献类型：
--
作者：
Contreras, A.;Herrera, J. A.;Botero, J. E.
背景：最近的研究表明牙周炎与妊娠并发症之间存在正相关。本研究的目的是确定牙周炎和龈下微生物组成对先兆子痫的影响。方法：在哥伦比亚卡利进行了一项病例对照研究，纳入了 130 名先兆子痫和 243 名非先兆子痫女性，妊娠期 26 至 36 周。两组均测定了社会人口统计学数据、产科危险因素、牙周状况和龈下微生物组成。先兆子痫的定义为血压> 140/90 mm Hg，并且>= 2+蛋白尿，通过0.3 g蛋白尿/24小时尿液样本证实。对照组是健康的孕妇。计算牙周炎和龈下微生物群组成的比值比 (OR)。 结果：130 名先兆子痫女性中共有 83 名 (63.8%) 和 243 名对照者中 89 名 (36.6%) 患有慢性牙周炎（OR：3.0；95% 置信区间 (Cl)：1.91 至 4.87；P < 0.001）。与对照组（3.0 +/- 0.08 mm）相比，病例组（4.0 +/- 0.10 mm）临床依恋丧失增加（P < 0.001）。先兆子痫母亲的平均新生儿出生体重为 2.453 克，而对照组为 2.981 克（P < 0.001）。两种红色复合微生物牙龈卟啉单胞菌和福赛坦氏菌以及绿色复合微生物腐蚀艾肯氏菌在先兆子痫组中的患病率高于对照组（P < 0.01）。结论：慢性牙周病以及牙龈卟啉单胞菌、福赛坦氏菌和腐蚀艾肯氏菌的存在与孕妇先兆子痫显着相关。需要进一步研究来确定活动性牙周病和与先兆子痫发展相关的龈下牙周病原体的致病机制。
Background: Recent investigations have demonstrated a positive association between periodontitis and pregnancy complications. The purpose of this study was to determine the effect of periodontitis and the subgingival microbial composition on preeclampsia.Methods: A case-control study was carried out in Cali, Colombia that included 130 preeclamptic and 243 non-preeclamptic women between 26 to 36 weeks of pregnancy. Sociodemographic data, obstetric risk factors, periodontal status, and subgingival microbial composition were determined in both groups. Preeclampsia was defined as blood pressure > 140/90 mm Hg, and >= 2+ proteinuria, confirmed by 0.3 g proteinuria/24 hours of urine specimens. Controls were healthy pregnant women. Odds ratios (ORs) for periodontitis and subgingival microbiota compositions were calculated.Results: A total of 83 out of 130 preeclamptic women (63.8%) and 89 out of 243 controls (36.6%) had chronic periodontitis (OR: 3.0; 95% confidence interval (Cl): 1.91 to 4.87; P < 0.001). Clinical attachment loss increased in the case group (4.0 +/- 0.10 mm) compared to the control group (3.0 +/- 0.08 mm) (P < 0.001). The average newborn birth weight from preeclamptic mothers was 2.453 g, whereas in controls was 2.981 g (P < 0.001). Two red complex microorganisms, Porphyromonas gingivalis and Tannerella forsythensis, and the green complex microorganism Eikenella corrodens were more preva-lent in the preeclamptic group than in controls (P < 0.01).Conclusions: Chronic periodontal disease and the presence of P. gingiualis, T. forsythensis, and E. corrodens were significantly associated with preeclampsia in pregnant women. Further research is needed to establish pathogenic mechanisms of active periodontal disease and subgingival periodontopathogens related to preeclampsia development.