The biology and treatment of oligometastatic cancer.
The biology and treatment of oligometastatic cancer.
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DOI：
10.18632/oncotarget.3455
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发表时间：
2015-04-20
期刊：
影响因子：
--
通讯作者：
Pienta KJ
中科院分区：
文献类型：
--
作者：
Reyes DK;Pienta KJ
有限且可治疗的癌症转移的临床报告是一种存在于局部和广泛全身性疾病之间过渡区域的疾病状态，历史上有时会被注意到，现在被称为寡转移。寡转移诊断的后果是治疗模式的改变，即如果原发癌症部位（如果仍然存在）得到控制或切除，并且转移部位被消融（手术或放射），则可以实现延长的无病间隔，甚至可能治愈。现代分子诊断技术越来越接近能够确定单个转移沉积物在恶性肿瘤连续体中的位置。临床前模型刚刚开始为理解寡转移状态奠定基础。与此同时，在临床上，由于诊断成像的改进、有可能提供直接或桥接治疗的新治疗方案以及寡转移定义的逐渐广泛，越来越多的患者被指定为患有寡转移疾病并接受治疗。
Clinical reports of limited and treatable cancer metastases, a disease state that exists in a transitional zone between localized and widespread systemic disease, were noted on occasion historically and are now termed oligometastasis. The ramification of a diagnosis of oligometastasis is a change in treatment paradigm, i.e. if the primary cancer site (if still present) is controlled, or resected, and the metastatic sites are ablated (surgically or with radiation), a prolonged disease-free interval, and perhaps even cure, may be achieved. Contemporary molecular diagnostics are edging closer to being able to determine where an individual metastatic deposit is within the continuum of malignancy. Preclinical models are on the outset of laying the groundwork for understanding the oligometastatic state. Meanwhile, in the clinic, patients are increasingly being designated as having oligometastatic disease and being treated owing to improved diagnostic imaging, novel treatment options with the potential to provide either direct or bridging therapy, and progressively broad definitions of oligometastasis.
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影响因子：
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