Nanoparticle uptake by the oral route: Fulfilling its potential?
Nanoparticle uptake by the oral route: Fulfilling its potential?
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DOI：
10.1016/j.ddtec.2005.05.019
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Florence, Alexander T
中科院分区：
文献类型：
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作者：
Florence, Alexander T
首先从最近的历史角度讨论了纳米颗粒从胃肠道的吸收，强调了影响吸收的关键参数，如颗粒直径，颗粒的性质以及与受体相互作用的配体的任何表面修饰，以促进靶向和吸收进入细胞。吸收后事件，包括易位过程，在这里被认为与肠道相关淋巴组织上皮细胞或m细胞的初始摄取同样重要。
The absorption of nanoparticles from the gastrointestinal tract is discussed first from a recent historical perspective, emphasising the crucial parameters that influence uptake, such as particle diameter, the nature of the particle and any surface modification with ligands designed to interact with receptors to facilitate targeting to and uptake into cells. Post-absorptive events, including translocation processes, are suggested here to be as important as initial uptake into the epithelial cells or M-cells of the gut associated lymphoid tissue.: