Cardiovascular Calcifications in Old Age: Mechanisms and Clinical Implications
Cardiovascular Calcifications in Old Age: Mechanisms and Clinical Implications
复制标题
DOI：
10.1007/s13670-013-0063-4
复制
发表时间：
2013-12-01
影响因子：
1.2
通讯作者：
Ferrucci, Luigi
中科院分区：
文献类型：
--
作者：
Giallauria, Francesco;Vigorito, Carlo;Ferrucci, Luigi
血管钙化是衰老的标志，在高血压、糖尿病和慢性肾病患者中加速。它可以被视为抑制剂和促进剂之间复杂和微妙的平衡紊乱的结果，在系统和局部水平上发挥作用。动脉粥样硬化过程中某些成分的种族差异先前已被确定;然而，最近的证据表明，动脉粥样硬化不是一种现代疾病，可能被视为人类衰老的固有组成部分，与任何特定的饮食或生活方式无关。在这篇综述中，我们强调了血管钙化的机制及其与衰老的关系。通过了解这些过程中涉及的途径，可以提出新的药物靶点，以减少血管钙化作为风险因素的影响。
Vascular calcification, a hallmark of aging, is accelerated in patients with hypertension, diabetes, and chronic kidney disease. It may be viewed as the result of disturbances of the complex and subtle balance between inhibitors and promoters, acting at both the systemic and local levels. Ethnic differences in certain components of the atherosclerosis process were identified previously; however, recent evidence suggests that atherosclerosis is not a modern disease and may be viewed as an inherent component of human aging, unrelated to any specific diet or lifestyle. In this review, we highlight the mechanisms governing vascular calcification and its association with aging. By understanding the pathways involved in these processes, novel drug targets may be proposed in an effort to reduce the effects of vascular calcification as a risk factor.