RNA Regulated Toxin-Antitoxin Systems in Pathogenic Bacteria.
RNA Regulated Toxin-Antitoxin Systems in Pathogenic Bacteria.
复制标题
DOI：
10.3389/fcimb.2021.661026
复制
发表时间：
2021
影响因子：
5.7
通讯作者：
Murphy ER
中科院分区：
文献类型：
--
作者：
Sarpong DD;Murphy ER
动态的宿主环境是病原菌生存和致病必须克服的一个重大障碍。因此，这些生物体已经进化出分子机制，以促进适应受感染宿主内的环境变化。小RNA（small RNA，sRNA）是致病菌中多种途径和系统的关键调节因子，包括细菌毒素-抗毒素（Toxin-Antitoxin，TA）系统。TA系统通常由两种因子组成，稳定的毒素和不稳定的抗毒素，其功能是保护免受相关毒素的潜在有害活性。在迄今为止表征的六类细菌TA系统中，毒素组分总是蛋白质。I型和III型TA系统的独特之处在于这些系统中的抗毒素是RNA分子，而所有其他TA系统中的抗毒素是蛋白质。虽然激烈的争论，TA系统在细菌生理学的参与是公认的几项研究，与II型TA系统是迄今为止最广泛的研究。本文综述了RNA调控的TA系统，强调了I型和III型TA系统在几种病原菌中的作用。
The dynamic host environment presents a significant hurdle that pathogenic bacteria must overcome to survive and cause diseases. Consequently, these organisms have evolved molecular mechanisms to facilitate adaptation to environmental changes within the infected host. Small RNAs (sRNAs) have been implicated as critical regulators of numerous pathways and systems in pathogenic bacteria, including that of bacterial Toxin-Antitoxin (TA) systems. TA systems are typically composed of two factors, a stable toxin, and a labile antitoxin which functions to protect against the potentially deleterious activity of the associated toxin. Of the six classes of bacterial TA systems characterized to date, the toxin component is always a protein. Type I and Type III TA systems are unique in that the antitoxin in these systems is an RNA molecule, whereas the antitoxin in all other TA systems is a protein. Though hotly debated, the involvement of TA systems in bacterial physiology is recognized by several studies, with the Type II TA system being the most extensively studied to date. This review focuses on RNA-regulated TA systems, highlighting the role of Type I and Type III TA systems in several pathogenic bacteria.