ARTICULAR CHONDROCALCINOSIS - MICROANALYSIS OF PYROPHOSPHATE (PPI) IN SYNOVIAL-FLUID AND PLASMA
ARTICULAR CHONDROCALCINOSIS - MICROANALYSIS OF PYROPHOSPHATE (PPI) IN SYNOVIAL-FLUID AND PLASMA
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DOI：
10.1002/art.1780160206
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发表时间：
1973-01-01
影响因子：
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通讯作者：
HOWELL, DS
中科院分区：
文献类型：
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作者：
ALTMAN, RD;MUNIZ, OE;HOWELL, DS
建立了一种新的微量测定方法，精密度为±5%，用于定量滑液和血浆中的焦磷酸盐，起始体积为0.5 ml。除了假性痛风受试者的滑液中明确升高外，在一些骨关节炎和痛风性关节炎患者中还发现滑液焦磷酸盐浓度高度显著升高。类风湿性关节炎患者或正常人血浆和滑液之间无焦磷酸盐梯度。对反映炎症的各种参数的研究未能显示假痛风患者焦磷酸盐浓度的相关性。
A new microassay method with precision of ±5% was developed to quantitate pyrophosphate in synovial fluid and plasma with starting volumes of 0.5 ml. A highly significant elevation of synovial fluid pyrophosphate concentration was found in some patients with osteoarthritis and gouty arthritis in addition to the well‐established elevation in synovial fluid of subjects with pseudogout. No gradient of pyrophosphate between plasma and synovial fluid of patients with rheumatoid arthritis or in normal subjects was detectable. Studies of various parameters reflecting inflammation failed to show a correlation with the concentration of pyrophosphate in patients with pseudogout.