Importance of the Major Histocompatibility Complex (Swine Leukocyte Antigen) in Swine Health and Biomedical Research
Importance of the Major Histocompatibility Complex (Swine Leukocyte Antigen) in Swine Health and Biomedical Research
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DOI：
10.1146/annurev-animal-020518-115014
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Lunney, Joan K.
中科院分区：
文献类型：
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作者：
Hammer, Sabine E.;Ho, Chak-Sum;Lunney, Joan K.
在猪中，主要组织相容性复合体（MHC）或猪白细胞抗原（SLA）复合体定位于野猪7号染色体。它由三个区域组成，I类和III类区域映射到7p1.1，II类区域映射到7q1.1。猪的MHC由着丝粒分开，这在迄今为止研究的哺乳动物中是独特的。SLA复合体的跨度在2.4和2.7 Mb之间，取决于单倍型，并且编码大约150个基因座，其中至少120个基因被预测为是功能性的。在这里，我们更新了整个SLA复杂的基础上Sscrofa 11.1构建和注释组织所有公认的SLA基因及其等位基因序列。我们提出SLA命名和分型方法，并讨论SLA蛋白的表达，以及它们在抗原呈递和免疫，疾病和疫苗反应中的作用。最后，我们探讨了SLA基因在移植和异种移植中的作用及其在猪生物医学模型中的重要性。
In pigs, the major histocompatibility complex (MHC), or swine leukocyte antigen (SLA) complex, maps to Sus scrofa chromosome 7. It consists of three regions, the class I and class III regions mapping to 7p1.1 and the class II region mapping to 7q1.1. The swine MHC is divided by the centromere, which is unique among mammals studied to date. The SLA complex spans between 2.4 and 2.7 Mb, depending on haplotype, and encodes approximately 150 loci, with at least 120 genes predicted to be functional. Here we update the whole SLA complex based on the Sscrofa11.1 build and annotate the organization for all recognized SLA genes and their allelic sequences. We present SLA nomenclature and typing methods and discuss the expression of SLA proteins, as well as their role in antigen presentation and immune, disease, and vaccine responses. Finally, we explore the role of SLA genes in transplantation and xenotransplantation and their importance in swine biomedical models.