PDE1 isozymes, key regulators of pathological vascular remodeling.
PDE1 isozymes, key regulators of pathological vascular remodeling.
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DOI：
10.1016/j.coph.2011.09.002
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发表时间：
2011-12
影响因子：
4
通讯作者：
Yan, Chen
中科院分区：
文献类型：
--
作者：
Chan, Stefan;Yan, Chen
病理性血管重塑是大多数血管疾病的特征，如动脉粥样硬化、血管成形术后再狭窄、同种异体血管病变和肺动脉高压。病理性血管重塑是一个多细胞依赖的过程，导致血管结构的不利改变，最终导致血管闭塞。环核苷酸信号调节从细胞收缩到细胞生长的各种血管功能。环核苷酸磷酸二酯酶(PDE)是一大类结构和功能不同的同工酶，通过催化其降解反应来调节环核苷酸水平和区域化。越来越多的证据表明，特异性环核苷酸调节的重要机制之一是通过选择性地激活或抑制不同的PDE同工酶来实施的。本文综述了PDE1同工酶在病理性血管重构中的作用和治疗潜力的研究进展。
Pathological vascular remodeling is a hallmark of most vascular disorders such as atherosclerosis, postangioplasty restenosis, allograft vasculopathy, and pulmonary hypertension. Pathological vascular remodeling is a multi-cell dependent process leading to detrimental changes of vessel structure and eventual vessel occlusion. Cyclic nucleotide signaling regulates a variety of vascular functions ranging from cell contractility to cell growth. Cyclic nucleotide phosphodiesterases (PDEs), a large family of structurally and functionally distinct isozymes, regulate cyclic nucleotide levels and compartmentalization through catalyzing their degradation reaction. Increasing evidence has suggested that one of the important mechanisms for specific cyclic nucleotide regulation is exerted through selective activation or inhibition of distinct PDE isozymes. This review summarizes the work done to characterize the role and therapeutic potential of PDE1 isozymes in pathological vascular remodeling.
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影响因子：
5.8
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1161/atvbaha.110.212621
发表时间：
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期刊：
Arteriosclerosis, thrombosis, and vascular biology
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影响因子：
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影响因子：
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