Transmission of SEN virus from mothers to their babies
Transmission of SEN virus from mothers to their babies
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DOI：
10.1002/jmv.2162
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发表时间：
2002-03-01
影响因子：
12.7
通讯作者：
Imberti, L
中科院分区：
文献类型：
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作者：
Pirovano, S;Bellinzoni, M;Imberti, L
从30名妇女在高风险的感染，其中一半是SEN病毒阳性（SENV+），血清收集在分娩研究SENV母婴传播。其中13名婴儿至少对一种SENV菌株呈阳性：一名婴儿出生时为SENV+，八名婴儿在分娩后6个月内呈阳性，四名婴儿在随后的几个月内呈阳性。我们的数据表明，垂直传播SENV确实发生，大概，在交付，但它可能不会引起持续的病毒血症。这一点得到以下事实的支持：通常，SENV在出生时未被检测到，在母亲及其子女中发现的序列中SENV同源性高，缺乏婴儿感染的其他风险因素，以及在随访中不规则地检测到SENV。没有发现与SENV感染相关的临床事件，但在长期随访的婴儿中观察到丙氨酸氨基转移酶一过性升高。(C)2002 Wiley-Liss，Inc.
Sera from 30 women at high risk for infection, one half of which were SEN virus positive (SENV+), were collected at delivery to study SENV mother-to child transmission. Thirteen of their babies were positive for at least one SENV strain: one baby was SENV+ at birth, eight became positive within 6 months from delivery, and four became positive in the following months. Our data indicate that vertical transmission of SENV does occur, presumably, at delivery, but it may not induce persistent viremia. This is supported by the fact that, generally, SENV is not detected at birth, by the high SENV homology in the sequences found in the mothers and in their children, by a lack of other risk factors for infection of the babies, and by the irregular detection of SENV in the follow-up. No clinical events surely linked to SENV infection were found, but transient elevations of alanine aminotransferase were observed in babies followed for a long period of time. (C) 2002 Wiley-Liss, Inc.