HIPPOCAMPECTOMIZED MONKEYS CAN REMEMBER ONE PLACE BUT NOT 2
HIPPOCAMPECTOMIZED MONKEYS CAN REMEMBER ONE PLACE BUT NOT 2
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DOI：
10.1016/0028-3932(93)90030-4
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发表时间：
1993-10-01
期刊：
影响因子：
2.6
通讯作者：
MISHKIN, M
中科院分区：
文献类型：
--
作者：
ANGELI, SJ;MURRAY, EA;MISHKIN, M
在帕金森等人的一项早期研究中（J.神经科学，8,4159 -4167,1988 b[26]），海马切除的猴子被发现在一项任务中受到损害，该任务要求它们记住三孔测试托盘中覆盖在两个孔上的试验独特物体的空间位置。在这项任务中有两种类型的试验。一种类型（物体-地点）需要存储对象质量和对象位置的关联，而另一种类型（地点）只需要存储对象的位置，即与对象质量无关。海马体切除的猴子在这两种试验中的表现几乎都是偶然的。目前的研究试图确定，切除海马的猴子在只有地点的试验中表现不佳，是否与空间延迟反应（一种在使用类似的短延迟时不受海马切除术影响的能力）非常相似，可能是由于它们在物体-地点试验中接受的同时训练的干扰。为此，我们检查了海马体移除对“只进行位置”试验类型的表现的影响，因为这是唯一的训练。在本研究中，海马切除的猴子被发现与早期研究中的猴子一样严重受损，因此排除了上述可能的解释。由于这种改进版的空间延迟反应的表现，与具有相同延迟的经典版的表现不同，严重依赖于海马体，因此似乎海马体切除术的猴子可以在短时间延迟后记住一个地方，而不是两个地方。
In an earlier study by PARKINSON et al. (J. Neurosci. 8, 4159-4167, 1988 [26]), hippocampectomized monkeys were found to be impaired on a task in which they were required to remember the spatial positions of trial-unique objects overlying two of the wells in a three-well test tray. There were two types of trial in the task. One type (object-place) required memory for the conjunction of object quality and object location, whereas the other (place only) required memory only for the location of the objects, i.e. independent of object quality. The hippocampectomized monkeys performed at near chance levels on both types of trials. The present study sought to determine whether the poor performance of the hippocampectomized monkeys on the place-only trials, which closely resembled spatial delayed response (an ability that is unaffected by hippocampectomy when similarly short delays are used), could have been due to interference from the simultaneous training they had received on the object-place trials. To this end, we examined the effect of hippocampal removals on performance of the ''place-only'' trial type when that was the only training given. The hippocampectomized monkeys in the present study were found to be just as severely impaired as those in the earlier study, thus ruling out the possible explanation outlined above. Since performance on this modified version of spatial delayed response, unlike performance on the classical version with the same delay, is critically dependent on the hippocampus, it appears that monkeys with hippocampectomy can remember one place after a short delay but not two.