Perirhinal cortex is necessary for acquiring, but not for retrieving object-place paired association.
Perirhinal cortex is necessary for acquiring, but not for retrieving object-place paired association.
复制标题
嗅周皮层是获取所必需的，但不是检索物体-地点配对关联所必需的。
DOI：
10.1101/lm.1620410
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Lee,Inah
中科院分区：
文献类型：
--
作者：
Jo,YongSang;Lee,Inah
记忆事件通常涉及将物体及其在空间中的相关位置联系起来，并且与海马体相关的区域在此功能中非常重要。目前的研究检查了嗅周皮层在检索熟悉的物体-位置配对联想以及获得新的联想中的作用。大鼠被要求访问一个径向臂迷宫的两个位置之一，并选择一个对象（从一对不同的玩具对象）专门与一个给定的arm. Excitotoxic病变的嗅周皮层最初损害了正常检索的对象-位置配对的联想记忆，已学习presperialically，但动物重新学习逐渐控制的水平。相比之下，当需要将一对新的物体与迷宫的相同位置相关联时，相同的损伤大鼠在整个广泛的测试期间发生了最小的学习（如果有的话）。然而，损毁的大鼠在辨别迷宫中固定臂中呈现的两个不同物体方面是正常的。结果表明，嗅周皮层是必不可少的形成离散表示的对象-地点配对协会。然而，当需要检索熟悉的对象-位置配对联想记忆时，它的作用可能会被其他结构所补偿。
Remembering events frequently involves associating objects and their associated locations in space, and it has been implicated that the areas associated with the hippocampus are important in this function. The current study examined the role of the perirhinal cortex in retrieving familiar object–place paired associates, as well as in acquiring novel ones. Rats were required to visit one of two locations of a radial-arm maze and choose one of the objects (from a pair of different toy objects) exclusively associated with a given arm. Excitotoxic lesions of the perirhinal cortex initially impaired the normal retrieval of object–place paired-associative memories that had been learned presurgically, but the animals relearned gradually to the level of controls. In contrast, when required to associate a novel pair of objects with the same locations of the maze, the same lesioned rats were severely impaired with minimal learning, if any, taking place throughout an extensive testing period. However, the lesioned rats were normal in discriminating two different objects presented in a fixed arm in the maze. The results suggest that the perirhinal cortex is indispensable to forming discrete representations for object–place paired associates. Its role, however, may be compensated for by other structures when familiar object–place paired associative memories need to be retrieved.