Immunohistochemically detectable Cdx2 is present in intestinal phenotypic elements in early gastric cancers of both differentiated and undifferentiated types, with no correlation to non-neoplastic surrounding mucosa
Immunohistochemically detectable Cdx2 is present in intestinal phenotypic elements in early gastric cancers of both differentiated and undifferentiated types, with no correlation to non-neoplastic surrounding mucosa
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DOI：
10.1111/j.1440-1827.2004.01647.x
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发表时间：
2004-06-01
影响因子：
2.2
通讯作者：
Tatematsu, M
中科院分区：
文献类型：
--
作者：
Mizoshita, T;Tsukamoto, T;Tatematsu, M
以前有报道称Cdx2是晚期胃癌（GC）有用的预后和肠道表型标志物。本研究检测了Cdx2在早期胃癌和非肿瘤性周围粘膜中的表达和表型。对130例早期胃癌（70例粘膜内癌和60例粘膜下浸润性癌）进行组织学和表型评估。免疫组织化学检测Cdx2的表达。病变表型分为44个胃型(G)、42个胃肠混合型（GI）、30个肠型(I)和14个空型(N)，与组织学分型无关。大多数早期GC为cdx2阳性，核染色与肠道表型表达密切相关。早期分化的肿瘤倾向于同时表达Cdx2和肠道表型，而未分化的肿瘤更可能只表达胃表型（P < 0.05）。6个粘膜内微癌的表型与邻近正常腺体的表型不相关。这些数据表明，Cdx2在胃癌发生的非常早期表达，并与从胃到肠道表型表达的转变有关。这似乎发生在分化的癌症比未分化的癌症更早的阶段，可能与抑制恶性细胞的扩张有关。
It has previously been reported that Cdx2 is the useful prognostic and intestinal phenotypic marker in advanced gastric cancers (GC). In this study, Cdx2 expression and phenotype in early GC and non-neoplastic surrounding mucosa were examined. A total of 130 early GC (70 intramucosal and 60 submucosally invasive cancers) histologically and phenotypically were evaluated. The expression of Cdx2 was assessed by immunohistochemistry. The lesions were phenotypically divided into 44 gastric (G), 42 gastric and intestinal mixed (GI), 30 intestinal (I), and 14 null (N) types, independent of the histological classification. Most of the early GC were Cdx2-positive, nuclear staining being strongly associated with intestinal phenotypic expression. Early differentiated cancers tended to feature both Cdx2 and intestinal phenotypic expression, while their undifferentiated counterparts were more likely to demonstrate only gastric phenotypic expression (P < 0.05). The phenotypes of six intramucosal microcarcinomas did not correlate with those of adjacent normal glands. These data suggest that Cdx2 is expressed in the very early stage of gastric carcinogenesis in association with the shift from gastric to intestinal phenotypic expression. This appears to occur in differentiated cancers at an earlier stage than in undifferentiated ones, and may be linked to suppression of expansion of malignant cells.