Role of surgeons in clinical trials for thyroid cancer.
Role of surgeons in clinical trials for thyroid cancer.
复制标题
外科医生在甲状腺癌临床试验中的作用。
DOI：
10.1007/s00268-006-0908-5
复制
发表时间：
2007
影响因子：
2.6
通讯作者：
WellsJr,SamuelA
中科院分区：
文献类型：
--
作者：
You,YNancy;WellsJr,SamuelA
正确的临床试验为循证医学实践提供了基础。外科医生在恶性实体瘤（包括甲状腺癌）患者的治疗中起着核心作用，因为恶性肿瘤的手术切除是有效治疗的重要第一步。本文讨论了外科医生在甲状腺癌临床研究中的作用，并回顾了影响甲状腺癌患者治疗的重要临床试验。最近的发现定义了各种类型甲状腺癌的基因突变，导致了靶向治疗的发展。这些化合物目前正在临床试验中进行评估，对于治疗局部晚期和远处转移性疾病患者具有很大的希望。外科研究者在临床试验中从患者身上获取肿瘤组织也起着重要作用。这些组织的分子分析在选择特定疗法和预测患者反应和预后方面至关重要。
AbstractProperly performed clinical trials provide a foundation for evidence‐based medical practice. The surgeon plays a central role in the management of patients with malignant solid tumors, including thyroid cancer, because operative extirpation of the malignancy is the essential first step in effective therapy. This article discusses the role of the surgeon in the clinical research of thyroid cancer and also reviews the important clinical trials that have influenced the treatment of patients with thyroid cancer. Recent discoveries defining the genetic mutations underlying the various types of thyroid cancers have led to the development of targeted therapies. These chemical compounds, which are now being evaluated in clinical trials, hold great promise for the treatment of patients with locally advanced and distant metastatic disease. The surgical investigator also plays an important role in procuring tumor tissue from patients in clinical trials. The molecular analysis of these tissues is of critical importance in selecting specific therapies and predicting patient response and prognosis.