Life and death of cardiac stem cells - A paradigm shift in cardiac biology
Life and death of cardiac stem cells - A paradigm shift in cardiac biology
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DOI：
10.1161/circulationaha.105.595181
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发表时间：
2006-03-21
期刊：
影响因子：
37.8
通讯作者：
Bolli, R
中科院分区：
文献类型：
--
作者：
Anversa, P;Kajstura, J;Bolli, R
被认为是不寻常的细胞，只在胚胎和胎儿发育期间产生，因此它们在心脏中的总数在出生时就确定了，在出生后、成年后或衰老期间不会进一步生长。这一范例驳斥了这样一种观点，即所有的心肌细胞都有相同的年龄，这些细胞的年龄与器官和有机体的年龄相对应。同样，这一范式表明，血管SMCs和ECs的周转和生长可能更多地受到CSCs分化的调控，而不是这些成熟细胞重新进入细胞周期和分裂的能力。因此，一个新的心脏概念框架出现了。心脏现在被视为一个自我更新的器官，在这个器官中，心肌细胞在整个生物体的生命周期中发生再生(图1)。心肌细胞是储存在壁龛中的常驻CSCs的后代。利基市场控制着
considered unusual cells that are created only during embryonic and fetal development so that their total number in the heart is established at birth and no further growth occurs postnatally, in adulthood, or during senescence. 2, 24 This paradigm refutes the belief that all cardiomyocytes have the same age and that the age of these cells corresponds to the age of the organ and organism. Similarly, this paradigm suggests that the turnover and growth of vascular SMCs and ECs may be regulated by differentiation of CSCs more than by the ability of these mature cells to reenter the cell cycle and divide.Thus, a new conceptual framework of the heart has emerged. The heart is now viewed as a self-renewing organ in which myocyte regeneration occurs throughout the organism lifespan (Figure 1). Myocytes are the progeny of resident CSCs stored in niches. The niches control the turnover of