Imaging of odor perception delineates functional disintegration of the limbic circuits in mesial temporal lobe epilepsy
Imaging of odor perception delineates functional disintegration of the limbic circuits in mesial temporal lobe epilepsy
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DOI：
10.1016/j.neuroimage.2007.09.004
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发表时间：
2008-01-15
期刊：
影响因子：
5.7
通讯作者：
Savic, Ivanka
中科院分区：
文献类型：
--
作者：
Ciumas, Carolina;Lindstroem, Per;Savic, Ivanka
内侧颞叶癫痫（MTLE）的病灶外边缘回路内的代谢和神经受体异常。然而，人们对这些电路如何处理外部刺激知之甚少。我们测试了气味激活是否有助于描绘MTLE中的边缘系统功能解体，并在出生时闻熟悉和不熟悉的气味时用PET测量脑血流量，使用无味空气作为基线条件。MTLE患者（13例左侧，10例右侧）和21例对照进行了研究。除了气味激活，分析还包括功能连接，使用左右梨状皮质作为种子区域，健康对照激活了两侧的杏仁核、梨状、前岛和扣带皮质。此外，熟悉的气味还涉及右侧海马旁区和左侧布罗德曼区（BA）44、45、47。患者未能激活致痫半球的杏仁核、梨状核和前岛叶皮质。此外，那些左侧MTLE没有激活左侧BA 44，45和47熟悉的气味，他们认为不太熟悉比对照组。与激活数据一致，患者的每个种子区域与对侧杏仁核+梨状核+岛叶皮质功能断开。功能解体的患者超过了减少激活，并包括对侧颞叶新皮质，并在受试者与右MTLE也是右眶额cort.Imaging气味知觉可用于描绘功能解体的边缘网络MTLE。它在几个区域显示出改变的反应，这可能是与这种情况相关的一些发作间期行为问题的基础。(C)2007年由Elsevier Inc.出版
Metabolic and neuro-receptor abnormalities within the extrafocal limbic circuits are established in mesial temporal lobe epilepsy (MTLE). However, very little is known about how these circuits process external stimuli. We tested whether odor activation can help delineate limbic functional disintegration in MTLE, and measured cerebral blood flow with PET during birhinal smelling of familiar and unfamiliar odors, using smelling of odorless air as the baseline condition. Patients with MTLE (13 left-sided, 10 right-sided) and 21 controls were investigated. In addition to odor activation, the analysis included functional connectivity, using right and left piriform cortex as seed regions.Healthy controls activated the amygdala, piriform, anterior insular, and cingulate cortices on both sides. Smelling of familiar odors engaged, in addition, the right parahippocampus, and the left Brodmann Area (BA) 44, 45, 47. Patients failed to activate the amygdala, piriform and the anterior insular cortex in the epileptogenic hemisphere. Furthermore, those with left MTLE did not activate the left BA 44, 45 and 47 with familiar odors, which they perceived as less familiar than controls. Congruent with the activation data each seed region was in patients functionally disconnected with the contralateral amygdala + piriform + insular cortex. The functional disintegration in patients exceeded the reduced activation, and included the contralateral temporal neocortex, and in subjects with right MTLE also the right orbitofrontal cortex.Imaging of odor perception may be used to delineate functional disintegration of the limbic networks in MTLE. It shows an altered response in several regions, which may underlie some interictal behavioral problems associated with this condition. (C) 2007 Published by Elsevier Inc.