Dose-dependent, amphetamine-induced changes in permeability of the blood-brain barrier of normotensive and spontaneously hypertensive rats.
Dose-dependent, amphetamine-induced changes in permeability of the blood-brain barrier of normotensive and spontaneously hypertensive rats.
复制标题
安非他明引起的正常血压和自发性高血压大鼠血脑屏障通透性的剂量依赖性变化。
DOI：
10.1016/0014-4886(80)90184-3
复制
发表时间：
1980
影响因子：
5.3
通讯作者：
Wellmeyer,D
中科院分区：
文献类型：
--
作者：
Domer,FR;Sankar,R;Cole,S;Wellmeyer,D
急性静脉注射安非他明可改变血脑屏障对~（131）I-放射性碘标记人血清白蛋白的通透性。在正常血压大鼠（WKY），反应是剂量依赖性和双相的。7.5 mg/kg或更低剂量的渗透性增加，15和30 mg/kg剂量的渗透性降低。自发性高血压大鼠（SHR）对苯丙胺的反应是完全不同的。生理盐水治疗的自发性高血压动物的血脑屏障的通透性大于生理盐水治疗的血压正常的动物。安非他明的剂量高达5毫克/公斤引起的渗透性增加，但远远低于在血压正常的动物。在7.5至30 mg/kg的安非他明剂量下，血脑屏障的渗透性没有显著变化。安非他明给药引起的血压急性变化与血脑屏障通透性变化之间存在高度相关性。
The permeability of the blood-brain barrier to131I-radioiodinated human serum albumin can be changed by the acute administration of amphetamine intravenously. In normotensive rats (WKY), the response was dose dependent and biphasic. The permeability was increased by doses of 7.5 mg/kg or less and the permeability was decreased by doses of 15 and 30 mg/kg. The response to amphetamine in spontaneously hypertensive rats (SHR) was quite different. The permeability of the blood-brain barrier was greater in the saline-treated spontaneously hypertensive animals than in the saline-treated normotensive animals. Doses of amphetamine to as much as 5 mg/kg caused an increase in permeability, but much less than was found in the normotensive animals. At doses of amphetamine from 7.5 to 30 mg/kg, there were no significant changes in permeability of the blood-brain barrier. There was a high correlation between the acute change in blood pressure caused by the administration of amphetamine and the change in permeability of the blood-brain barrier.