High-sensitivity C-reactive protein - Potential adjunct for global risk assessment in the primary prevention of cardiovascular disease
High-sensitivity C-reactive protein - Potential adjunct for global risk assessment in the primary prevention of cardiovascular disease
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DOI：
10.1161/01.cir.103.13.1813
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发表时间：
2001-04-03
期刊：
影响因子：
37.8
通讯作者：
Ridker, PM
中科院分区：
文献类型：
--
作者：
Ridker, PM
炎症在动脉粥样硬化血栓形成中起着重要作用，测量炎症标志物如高敏C反应蛋白（HSCRP）可能为检测斑块破裂高风险个体提供一种新方法。一些大规模的前瞻性研究表明，在表面健康的男性和女性中，HSCRP是未来心肌梗死和中风的一个强有力的独立预测因子，并且在标准脂质筛查中加入HSCRP可能会改善高胆固醇和低胆固醇水平人群的总体风险预测。因为药物如阿司匹林和他汀类药物似乎可以降低炎症风险，所以HSCRP也可以用于靶向已证实的一级预防治疗。廉价的商业检测HSCRP现在可用;他们已经显示出类似的胆固醇筛查的变异性和分类准确性。风险预测算法使用一个简单的五分位数的方法HSCRP评估已开发用于门诊使用。因此，尽管炎症筛查存在固有的局限性，但现有数据表明，HSCRP有可能在心血管疾病的一级预防中作为全球风险评估的辅助手段发挥重要作用。
Inflammation plays a major role in atherothrombosis, and measurement of inflammatory markers such as high-sensitivity C-reactive protein (HSCRP) may provide a novel method for detecting individuals at high risk of plaque rupture. Several large-scale prospective studies demonstrate that HSCRP is a strong independent predictor of future myocardial infarction and stroke among apparently healthy men and women and that the addition of HSCRP to standard lipid screening may improve global risk prediction among those with high as well as low cholesterol levels. Because agents such as aspirin and statins seem to attenuate inflammatory risk, HSCRP may also have utility in targeting proven therapies for primary prevention. Inexpensive commercial assays for HSCRP are now available; they have shown variability and classification accuracy similar to that of cholesterol screening. Risk prediction algorithms using a simple quintile approach to HSCRP evaluation have been developed for outpatient use. Thus, although limitations inherent to inflammatory screening remain, available data suggest that HSCRP has the potential to play an important role as an adjunct for global risk assessment in the primary prevention of cardiovascular disease.