A threshold dose of heavy ion radiation that decreases the oxidative enzyme activity of spinal motoneurons in rats
A threshold dose of heavy ion radiation that decreases the oxidative enzyme activity of spinal motoneurons in rats
复制标题
降低大鼠脊髓运动神经元氧化酶活性的阈剂量重离子辐射
DOI：
10.1007/s11064-011-0623-y
复制
发表时间：
2012
影响因子：
4.4
通讯作者：
Nojima K
中科院分区：
文献类型：
--
作者：
Ishihara A;Nagatomo F;Fujino H;Kondo H;Nojima K
研究了脊髓重离子辐射暴露对支配慢比目鱼肌和快跖肌的运动神经元特性的影响。将 15、20、40、50 或 70 Gy 剂量的碳离子（5 Gy/min）施加到大鼠脊髓的第二至第六腰段。经过 1 个月的恢复期后，无论接受的剂量如何，受辐射的支配比目鱼肌和跖肌的运动神经元的数量和细胞体大小与未受辐射的对照组没有差异。然而，与未辐射对照相比，这些运动神经元的氧化酶活性在 40、50 和 70 Gy 剂量的重离子辐射下降低。经过 6 个月的恢复期后，运动神经元中氧化酶活性水平的下降恢复到未受辐射对照的水平。我们得出的结论是，40-70 Gy 剂量的重离子辐射可逆地降低大鼠脊髓中运动神经元的氧化酶活性。
The effect of heavy ion radiation exposure of the spinal cord on the properties of the motoneurons innervating the slow soleus and fast plantaris muscles was investigated. A 15-, 20-, 40-, 50-, or 70-Gy dose of carbon ions (5 Gy/min) was applied to the 2nd to the 6th lumbar segments of the spinal cord in rats. After a 1-month recovery period, the number and cell body size of the irradiated motoneurons innervating the soleus and plantaris muscles did not differ from that of the non-irradiated controls, irrespective of the dose received. However, the oxidative enzyme activity of these motoneurons was decreased by heavy ion radiation at doses of 40, 50, and 70 Gy compared to that of the non-irradiated controls. This decrease in oxidative enzyme activity levels in the motoneurons returned to that of the non-irradiated controls after a 6-month recovery period. We conclude that heavy ion radiation at doses of 40–70 Gy reversibly decreases the oxidative enzyme activity of motoneurons in the spinal cord of rats.