Comparison of soft tissue response in rabbits following laryngeal implantation with hydroxylapatite, silicone rubber, and Teflon.
Comparison of soft tissue response in rabbits following laryngeal implantation with hydroxylapatite, silicone rubber, and Teflon.
复制标题
羟基磷灰石、硅橡胶和聚四氟乙烯喉部植入后家兔软组织反应的比较。
DOI：
10.1177/000348949710600508
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Cummings,CW
中科院分区：
文献类型：
--
作者：
Flint,PW;Corio,RL;Cummings,CW
本研究评价了使用羟基磷灰石假体、雕刻硅橡胶假体和可注射聚四氟乙烯进行喉内移植入后兔的软组织反应。16只家兔行左侧喉返神经切断术，喉内植入羟基磷灰石。在1、3、6和12个月时，无痛处死4只动物并进行组织学处理。同样，动物植入雕刻的硅橡胶假体或通过甲状腺板中的皮瓣注射Teflon，以在1、3和6个月时进行比较。在植入羟基磷灰石的动物中，组织学发现包括有限的急性炎症反应、薄纤维包裹和窗孔区域的骨生成，以及桥接植入物和甲状腺板之间空间的板层骨。对于硅橡胶假体，存在有限的炎症反应和植入物的纤维包裹，没有成骨的证据。植入Teflon的动物表现出典型的异物反应，包括多核巨细胞、肉芽肿形成和Teflon迁移到周围肌肉中。关于软组织反应，羟基磷灰石和硅橡胶的反应性均低于Teflon。在羟基磷灰石存在下观察到的骨生成增加了植入物稳定性并最大限度地降低了迁移风险。相反，骨生长的存在可能会限制使用羟基磷灰石进行的内侧化手术的可逆性。
This study evaluates the soft tissue response in rabbits following laryngeal implantation for medialization using hydroxylapatite prostheses, carved silicone rubber prostheses, and injectable Teflon. Sixteen rabbits underwent left recurrent laryngeal nerve section for denervation and laryngeal implantation with hydroxylapatite. At 1, 3, 6, and 12 months, 4 animals were painlessly sacrificed and processed for histology. Similarly, animals were implanted with carved silicone rubber prostheses or with Teflon injected through a flap in the thyroid lamina for comparison at 1,3, and 6 months. In animals implanted with hydroxylapatite, histologic findings include limited acute inflammatory response, thin fibrous encapsulation, and osteogenesis in the region of the fenestra, with lamellar bone bridging the space between the implant and thyroid lamina. With silicone rubber prostheses, there is a limited inflammatory response and fibrous encapsulation of the implant without evidence of osteogenesis. Animals implanted with Teflon demonstrated a classic foreign body reaction with multinucleated giant cells, granuloma formation, and migration of Teflon into surrounding muscle. With respect to soft tissue response, both hydroxylapatite and silicone rubber are less reactive than Teflon. The osteogenesis observed in the presence of hydroxylapatite increases implant stability and minimizes the risk of migration. Conversely, the presence of bone growth may limit the reversibility of medialization procedures performed with hydroxylapatite.