Recidivous acute urticaria caused by Anisakis simplex
Recidivous acute urticaria caused by Anisakis simplex
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单纯异尖线虫引起的复发性急性荨麻疹
DOI：
10.1111/j.1398-9995.1997.tb02418.x
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发表时间：
1997
期刊：
影响因子：
12.4
通讯作者：
C. Cuéllar
中科院分区：
文献类型：
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作者：
A. Montoro;M. J. Perteguer;T. Chivato;R. Laguna;C. Cuéllar
本研究旨在确定经常吃鱼或其他海鲜的患者发生急性复发性荨麻疹的原因。研究了25名患者。用异尖线虫幼虫提取物进行皮肤点刺试验，测定抗异尖线虫总IgE和特异性IgE。用CAP系统检测单纯型;用ELISA法检测血清中的单克隆抗体，用Western blot法检测血清中的免疫识别模式。19例患者显示A特异性IgE。仅2例患者表现出单纯的但特异的抗蛔虫IgE。使用相同的测试，没有患者对犬弓首线虫或细粒棘球绦虫抗原产生反应。16例患者皮肤点刺试验阳性，其中2例持续48 h。5例患者无皮肤反应，也无特异性IgE。单纯形血清中有抗A.通过ELISA和Western印迹，对单幼虫粗提物进行鉴定。同样，还通过ELISA测定了针对排泄-分泌抗原的特异性免疫球蛋白水平。只有一名患者对鱼过敏。A.发现单纯性荨麻疹是经常吃鱼而对鱼不敏感的患者急性复发性荨麻疹的主要原因。
This study aimed to determine the cause of acute recidivous urticaria in patients who usually eat fish or other seafood. Twenty‐five patients were studied. The skin prick test with larval Anisakis simplex extract was performed; total and specific IgE against A. simplex was measured with the CAP System; specific antibodies to A. simplex were determined by ELISA; and immunorecognition patterns of the sera were studied by Western blot. Nineteen patients showed specific IgE to A. simplex, but specific IgE to Ascaris was demonstrated in only two patients. No patients reacted to Toxocara canis or Echinoccocus granulosus antigens with the same test. The skin prick test was positive in 16 patients, in two of them persisting for 48 h. Five patients showed neither skin reaction nor specific IgE to A. simplex. Sera showed specific immunoglobulin levels against A. simplex larval crude extract, by both ELISA and Western blot. Likewise, specific immunoglobulin levels against excretory‐secretory antigen were also measured by ELISA. Only one patient showed sensitization to fish. A. simplex was found to be the main cause of acute recidivous urticaria in patients who usually eat fish and are not sensitized to it.
通过海洋食品传播的人类异尖线虫病。
DOI：
--
发表时间：
1991
期刊：
Hawaii medical journal
影响因子：
--
作者：
Deardorff,TL;Kayes,SG;Fukumura,T
通讯作者：
Fukumura,T