Synthesis of Thietanes from Saturated Three‐membered Heterocycles
Synthesis of Thietanes from Saturated Three‐membered Heterocycles
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DOI：
10.1002/ajoc.202000219
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发表时间：
2020-07
影响因子：
2.7
通讯作者：
Jiaxi Xu
中科院分区：
文献类型：
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作者：
Jiaxi Xu
硫杂环丁烷是一些生物化合物的重要结构单元，也是有机合成中的重要中间体。近年来，以容易获得的饱和三元杂环作为起始原料或关键中间体，开发了多种硫杂环丁烷的合成方法。饱和三元杂环-2-甲基卤化物和磺酸盐以及硫杂环丙烷都是广泛使用的材料。硫杂环丙烷的亲核扩环和亲电扩环是合成硫杂环丁烷的有效方法。在这篇焦点综述中，我们描述了从现成的应变和饱和三元杂环合成应变四元硫杂环硫杂环丁烷的各种策略。
Thietanes are important structural motifs of some biological compounds and useful intermediates in organic synthesis. Various synthetic methods of thietanes have been developed recently with readily available saturated three‐membered heterocycles as starting materials or key intermediates. Both saturated three membered heterocycle‐2‐methyl halides and sulfonates and thiiranes are widely utilized materials. Both nucleophilic and electrophilic ring expansions of thiiranes are efficient methods for synthesis of thietanes. In this Focus Review, we have described various strategies for the synthesis of strained four‐membered thiaheterocyclic thietanes from readily available strained and saturated three‐membered heterocycles.