ALZHEIMERS-DISEASE - A DISORDER OF CORTICAL CHOLINERGIC INNERVATION
ALZHEIMERS-DISEASE - A DISORDER OF CORTICAL CHOLINERGIC INNERVATION
复制标题
DOI：
10.1126/science.6338589
复制
发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
DELONG, MR
中科院分区：
文献类型：
--
作者：
COYLE, JT;PRICE, DL;DELONG, MR
目前非常重视神经和精神疾病症状性表现所涉及的神经递质系统的鉴定。在阿尔茨海默病的案例中，有令人信服的证据表明，位于基底前脑的乙酰胆碱释放神经元选择性地退化。阿尔茨海默病现在似乎是老年人智力恶化的最常见原因之一。这些胆碱能神经元为大脑皮层和相关结构提供广泛的神经支配，似乎在认知功能，特别是记忆中发挥着重要作用。这些进展反映了实验神经科学家和临床神经科学家之间的密切互动，在这些互动中，来自基础神经生物学的信息被迅速用于分析人类大脑的疾病。
Great emphasis is being placed on identification of neurotransmitter systems involved in the symptomatic manifestations of neurological and psychiatric disorders. In the case of Alzheimer's disease, which now seems to be one of the most common causes of mental deterioration in the elderly, compelling evidence has been developed that acetylcholine-releasing neurons, whose cell bodies lie in the basal forebrain, selectively degenerate. These cholinergic neurons provide widespread innervation of the cerebral cortex and related structures and appear to play an important role in cognitive functions, especially memory. These advances reflect a close interaction between experimental and clinical neuroscientists in which information derived from basic neurobiology is rapidly utilized to analyze disorders of the human brain.