Stillbirth and Fetal Growth Restriction
Stillbirth and Fetal Growth Restriction
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DOI：
10.1097/grf.0b013e3181eba0db
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发表时间：
2010-09-01
影响因子：
1.5
通讯作者：
Bukowski, Radek
中科院分区：
文献类型：
--
作者：
Bukowski, Radek
死产和胎儿生长受限之间的联系是强有力的，有大量证据支持，并在临床上用于死产预测。然而，尽管评估胎儿生长发育是临床实践的基础，但它并不是微不足道的。从本质上讲，胎儿的生长是胎儿遗传生长潜力和胎盘功能的结果。生长潜能是胎儿生长的驱动力，而胎盘作为唯一的营养和氧气来源，如果其功能受损，则可能成为胎儿生长的限速因素。因此，胎盘功能障碍可能会阻止胎儿充分发挥其基因决定的生长潜力。从这个意义上讲，胎儿的生长及其异常提供了对胎盘功能的洞察。胎儿生长发育是检验胎盘有效性的指标，胎盘的功能在怀孕期间会被遮蔽。
The association between stillbirth and fetal growth restriction is strong and supported by a large body of evidence and clinically employed for the stillbirth prediction. However, although assessment of fetal growth is a basis of clinical practice, it is not trivial. Essentially, fetal growth is a result of the genetic growth potential of the fetus and placental function. The growth potential is the driving force of fetal growth, whereas the placenta as the sole source of nutrients and oxygen might become the rate limiting element of fetal growth if its function is impaired. Thus, placental dysfunction may prevent the fetus from reaching its full genetically determined growth potential. In this sense fetal growth and its aberration provides an insight into placental function. Fetal growth is a proxy for the test of the effectiveness of placenta, whose function is otherwise obscured during pregnancy.