Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males
Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males
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DOI：
10.1073/pnas.93.24.14100
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发表时间：
1996-11-26
影响因子：
11.1
通讯作者：
Veldhuis, JD
中科院分区：
文献类型：
--
作者：
Pincus, SM;Mulligan, T;Veldhuis, JD
关于黄体生成素（LH）和睾酮（T）分泌模式的新统计观点可能有助于进一步了解衰老过程，并可能最终改善精子发生失败和性兴趣丧失的诊断和治疗，我们检查了14名年轻人血清LH和T浓度的时间序列，（21-34岁）和II岁（67-74岁）健康男性，对于每个受试者，在睡眠期间以2.5分钟的间隔获得血液样品？对于LH和T，我们使用模型独立统计近似熵（ApEn）来量化血清浓度时间序列的不规则性;对于LH-T联合分泌的不规则性，我们使用最近引入的交叉ApEn。虽然意思！LH和T浓度在两个年龄组中没有区别对于LH，老年受试者的ApEn值更大（P > 0.25），（1.525 +/- 0.221）比年轻人（1.207 ± 0.252），P < 0.003，提示老年组的不规则分泌更多。对于T，老年受试者的ApEn值也更大（1，622 +/- 0.120）比年轻的同行（1.384 ± 0.228），P < 0.004，在年轻男性中，ApEn（T）显著高于ApEn（LH），P < 0.02，而老年男性的交叉ApEn值更大（1.961 +/- 0.121）（1.574 +/- 0.249），P < 10（-4），敏感性和特异性接近100%，表明老年组中LH-T水平更高，与先前发现的生长激素释放随年龄增加更不规则相结合，我们提出，随着年龄的增长，分泌不规则性的增加可能是一种普遍的激素现象，最后，理论上，我们通过对“可变滞后”脉动过程的研究，阐明了定量如近似熵和交叉近似熵的必要性，并根据经验指出交叉近似熵在量化相互连接的（激素）网络中的不规则性方面的潜在广泛适用性。
New statistical perspectives on the secretory patterns of both luteinizing hormone (LH) and testosterone (T) may prove useful in further understanding the aging process, and possibly ultimately in improving the diagnosis and treatment of spermatogenetic failure and loss of sexual interest, We examined serum concentration time-series for LH and T in 14 young (21-34 gears of age) and II aged (67-74 years of age) healthy men, For each subject, blood samples were obtained at 2.5-min intervals during a sleep period? with an average sampling duration of 7 hr, For each of LH and T, we used the model-independent statistic approximate entropy (ApEn) to quantify the irregularity of the serum concentration time-series; to quantify joint LH-T secretory asynchrony, we employed the recently introduced cross-ApEn. Although mean !and SD) LH and T concentrations were indistinguishable in the two age groups (P > 0.25), for LH, aged subjects had greater ApEn values (1.525 +/- 0.221) than younger individuals (1.207 +/- 0.252), P < 0.003, indicating more irregular secretion in the older cohort, For T, aged subjects also had greater ApEn values (1,622 +/- 0.120) than younger counterparts (1.384 +/- 0.228), P < 0.004, In young, but not older men, ApEn(T) significantly exceeded ApEn(LH), P < 0.02, Aged subjects had greater cross-ApEn values (1.961 +/- 0.121) than younger subjects (1.574 +/- 0.249), P < 10(-4), with nearly 100% sensitivity and specificity, indicating greater LH-T asynchrony in the older group, In conjunction with previous findings of greater irregularity of growth hormone release with increasing age, we propose that increased secretory irregularity with advancing age may be a widespread hormonal phenomenon, Finally, theoretically, we clarify the need for quantifications such as ApEn and cross-ApEn via a study of a ''variable lag'' pulsatile process, and empirically note the potential wide applicability of cross-ApEn to quantify asynchrony in interconnected (hormonal) networks.