Endogenous cholecystokinin's satiating action increases during estrus in female rats
Endogenous cholecystokinin's satiating action increases during estrus in female rats
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DOI：
10.1016/s0196-9781(99)00025-x
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发表时间：
1999-01-01
期刊：
影响因子：
3
通讯作者：
Geary, N
中科院分区：
文献类型：
--
作者：
Eckel, LA;Geary, N
雌性Long-Evans大鼠在发情期进食量和食量减少。为探讨内源性胆囊收缩素(CCK)的饱腹作用对此的贡献，在发情间期、进食量最大时和发情期最少时，分别注射1 mg/kg的CCK受体拮抗剂地西吡特。在发情期，地西吡特可增加自发摄食量和进食量，但在发情间期则不增加。进食频率不受地西平治疗的影响。这些结果表明，CCK饱腹感信号系统的效力在发情期增强。(C)1999 Elsevier Science Inc.保留所有权利。
Food intake and meal size are reduced in female Long-Evans rats during estrus. To investigate the contribution of the satiating action of endogenous cholecystokinin (CCK) to this, rats were injected with 1 mg/kg of the potent, selective CCK, receptor antagonist, devazepide, during diestrus, when meal size is maximal, and during estrus, when it is minimal. Devazepide increased spontaneous food intake and meal size during estrus, but not during diestrus. Meal frequency was not affected by devazepide treatment. These results indicate that the potency of the CCK satiety-signaling system increases during estrus. (C) 1999 Elsevier Science Inc. All rights reserved.