Translational Landscape of mTOR Signaling in Integrating Cues Between Cancer and Tumor Microenvironment
Translational Landscape of mTOR Signaling in Integrating Cues Between Cancer and Tumor Microenvironment
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DOI：
10.1007/978-3-030-35582-1_4
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发表时间：
2020-01-01
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影响因子：
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通讯作者：
Ciuffreda, Ludovica
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文献类型：
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作者：
Bazzichetto, Chiara;Conciatori, Fabiana;Ciuffreda, Ludovica
哺乳动物雷帕霉素靶蛋白（mTOR）是调节正常细胞和肿瘤细胞中不同过程的关键枢纽。此外，现在已经很好地确定了mTOR在整合和形成肿瘤微环境（TME）成分中的不同环境旁分泌和自分泌刺激中的作用。近年来，mTOR信号转导机制在调节肿瘤细胞对靶向治疗的敏感性和耐药性方面的作用以及mTOR在调节血管生成和肿瘤免疫中的作用已被越来越多的研究者所关注。事实上，对mTOR靶向的兴趣增加，以改善对癌症的免疫应答并开发新的长期疗效策略，如mTOR和免疫检查点抑制剂组合的临床成功所证明的。在本章中，我们将描述mTOR在调节TME元件中的作用以及其靶向作用在临床试验中的巨大前景。
The mammalian target of rapamycin (mTOR) represents a critical hub for the regulation of different processes in both normal and tumor cells. Furthermore, it is now well established the role of mTOR in integrating and shaping different environmental paracrine and autocrine stimuli in tumor microenvironment (TME) constituents. Recently, further efforts have been employed to understand how the mTOR signal transduction mechanisms modulate the sensitivity and resistance to targeted therapies, also for its involvement of mTOR also in modulating angiogenesis and tumor immunity. Indeed, interest in mTOR targeting was increased to improve immune response against cancer and to develop new long-term efficacy strategies, as demonstrated by clinical success of mTOR and immune checkpoint inhibitor combinations. In this chapter, we will describe the role of mTOR in modulating TME elements and the implication in its targeting as a great promise in clinical trials.