Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity.
Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity.
复制标题
纳米二氧化硅和聚丙烯酸酯/纳米二氧化硅：急性毒性的比较研究
DOI：
10.1155/2016/9353275
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发表时间：
2016
影响因子：
--
通讯作者：
Song YG
中科院分区：
文献类型：
--
作者：
Niu YM;Zhu XL;Chang B;Tong ZH;Cao W;Qiao PH;Zhang LY;Zhao J;Song YG
We compared the acute toxicity of nanosilica and polyacrylate/nanosilica instillation in Wistar rats (n = 60). Exposure to nanosilica and polyacrylate/nanosilica showed a 30% mortality rate. When compared with saline-treated rats, animals in both exposure groups exhibited a significant reduction of PO2 (P < 0.05) at both 24 and 72 hr. after exposure. Both exposure groups exhibited a significant reduction of neutrophils in arterial blood compared to saline controls (P < 0.05) 24 hr. after exposure. The levels of blood ALT and LDH in exposed groups were found to be significantly increased (P < 0.05) 24 hr. following exposure. The exposed groups exhibited various degrees of pleural effusion and pericardial effusion. Our findings indicated respiratory exposure to polyacrylate/nanosilica and nanosilica is likely to cause multiple organ toxicity.
