Possible association of the alpha-2A-adrenergic receptor gene with response time variability in attention deficit hyperactivity disorder
Possible association of the alpha-2A-adrenergic receptor gene with response time variability in attention deficit hyperactivity disorder
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DOI：
10.1002/ajmg.b.30725
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发表时间：
2008-09-05
影响因子：
2.8
通讯作者：
Park, Tae-Won
中科院分区：
文献类型：
--
作者：
Cho, Soo-Churl;Kim, Jae-Won;Park, Tae-Won
先前的研究表明，α2A 肾上腺素受体基因 (ADRA2A) 的 MspI 和 DraI 多态性与 ADHD 相关。然而，很少有研究旨在确定 ADRA2A 基因型与 ADHD 神经认知测量表现之间的关联。本研究的目的是检查 ADRA2A MspI 和 Dral 多态性与韩国受试者 ADHD 的关联，并确定这两种多态性的基因型与候选内表型之间的关系，通过连续性能测试 (CPT) 测量。在一项病例对照研究中，我们评估了 186 名 ADHD 先证者和 150 名正常对照。基于家庭的关联分析对一百八个三人组进行了研究。传递不平衡。测试（TDT）分析显示DraI多态性的C等位基因优先传递（chi(2)=5.88，P=0.015）。在单倍型分析中，观察到单倍型C/C的过度传播趋势（chi(2) = 3.80，P = 0.051）。 Dral 多态性 C 等位基因（C/C 基因型）的纯合受试者在 CPT 反应时间变异性方面表现出比其他基因型（C/T + T/T 基因型；P=0.042）更高的平均 T 分数趋势。 MspI 多态性处 G 等位基因（G/G 基因型）的纯合受试者。就 CPT 的响应时间变异性分布而言，显示出平均 T 分数较低的趋势 (P = 0.068)。这项研究的结果为 ADRA2A MspI 和 DraI 多态性参与韩国受试者 ADHD 病因学提供了重要证据。此外，我们的结果为这两种多态性在 ADHD 症状表达中可能发挥的作用提供了证据，例如反应时间变异性增加。 (c) 2008 年 Wiley-Liss, Inc.
Previous studies have demonstrated that the MspI and DraI polymorphisms at the alpha-2A-adrenergic receptor gene (ADRA2A) are associated with ADHD. However, few studies have been designed to ascertain the association between the ADRA2A genotypes and the performance on neurocognitive measures in ADHD. The aims of this study were to examine the association of the ADRA2A MspI and Dral polymorphisms with ADHD in Korean subjects, and to determine the relationship between the genotypes of these two polymorphisms and the candidate endophenotypes, as measured by the continuous performance test (CPT). In a case-control study, we assessed 186 ADHD probands and 150 normal controls. One hundred eight trios were studied in a family based association analysis. The transmission disequilibrium. test (TDT) analysis showed preferential transmission of the C allele of the DraI polymorphism (chi(2) =5.88, P = 0.015). In the haplotype analyses, a trend of over-transmission of haplotype C/C was observed (chi(2) = 3.80, P = 0.051). The homozygous subjects for the C allele (C/C genotype) at the Dral polymorphism showed a trend toward a higher mean T-score with respect to the response time variability profiles of the CPT than did those with the other genotypes (C/T + T/T genotypes; P=0.042). The homozygous subjects for the G allele (G/G genotype) at the MspI polymorphism. showed a tendency to have a lower mean T-score with respect to the response time variability profiles of the CPT (P = 0.068). The results of this study provide important evidence for the involvement of the ADRA2A MspI and DraI polymorphisms in the etiology of ADHD in Korean subjects. In addition, our results provide evidence for the possible role of these two polymorphisms in ADHD symptom expression, such as increased response time variability. (c) 2008 Wiley-Liss, Inc.