Identification of neural stem cells in the adult vertebrate brain
Identification of neural stem cells in the adult vertebrate brain
复制标题
DOI：
10.1016/s0361-9230(01)00770-5
复制
发表时间：
2002-04-01
影响因子：
3.8
通讯作者：
Doetsch, F
中科院分区：
文献类型：
--
作者：
Alvarez-Buylla, A;Seri, B;Doetsch, F
神经发生在受限制的生发层中持续到成年。鉴定产生这些新神经元的神经干细胞具有重要的临床意义，并为了解新神经元的起源提供了基础信息。对成年鸟类和啮齿类动物的研究得出了一个惊人的结果：神经干细胞似乎具有神经胶质细胞的特征。在成年鸟类中，主要的神经前体是放射状胶质细胞。在成年哺乳动物中，初级神经元前体具有星形胶质细胞的特性。放射状胶质细胞已经被证明可以转化为星形胶质细胞；这两种细胞类型通常被认为是星形胶质细胞谱系的一部分。相反，我们提出神经干细胞包含在这个星形胶质谱系中。这些在成年脊椎动物大脑中的发现，加上最近在哺乳动物大脑皮层发育中的研究，迫使我们重新审视关于中枢神经系统中神经元和神经胶质起源的传统观念。特别是，神经干细胞具有令人惊讶的复杂结构，这表明除了它们的祖细胞作用外，它们还具有重要的结构和代谢支持功能。产生新神经元的细胞似乎也会促进它们的成熟并支持它们的功能。(C) 2002爱思唯尔科学有限公司
Neurogenesis continues into adult life in restricted germinal layers. The identification of the neural stem cells that give rise to these new neurons has important clinical implications and provides fundamental information to understand the origins of the new neurons. Work in adult birds and rodents yielded a surprising result: the neural stem cells appear to have characteristics of glia. In adult birds, the primary neuronal precursors are radial glia. In adult mammals, the primary neuronal precursors have properties of astrocytes. Radial glial cells have previously been shown to transform into astrocytes; both cell types are classically considered part of a committed astroglial lineage. Instead, we propose that neural stem cells are contained within this astroglial lineage. These findings in adult vertebrate brain, together with recent work in the developing mammalian cerebral cortex, force us to reexamine traditional concepts about the origin of neurons and glia in the central nervous system. In particular, neural stem cells possess a surprisingly elaborate structure, suggesting that in addition to their progenitor role, they have important structural and metabolic support functions. The very same cells that give birth to new neurons also seem to nurture their maturation and support their function. (C) 2002 Elsevier Science Inc.