Tibial and femoral cartilage changes in knee osteoarthritis
Tibial and femoral cartilage changes in knee osteoarthritis
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DOI：
10.1136/ard.60.10.977
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发表时间：
2001-10-01
影响因子：
27.4
通讯作者：
Stuckey, SL
中科院分区：
文献类型：
--
作者：
Cicuttini, FM;Wluka, A;Stuckey, SL
背景：尽管在骨关节炎（OA）研究中使用膝关节软骨体积作为结果测量的兴趣越来越大，但尚不清楚膝关节软骨的哪些成分将最有用作为胫股关节（TF）结构的标记。目的：比较正常膝关节和骨关节炎膝关节股骨和胫骨软骨体积的变化及其与放射学分级的关系。方法：对82例膝关节骨性关节炎患者（女性44例，男性38例，年龄35-69岁）进行影像学检查。每个受试者的内侧和外侧TF关节的股骨和胫骨软骨体积由膝关节的T-1加权脂肪饱和磁共振图像确定。通过站立膝关节x线片确定OA的放射学分级。结果：股骨软骨体积与胫骨软骨体积之间有很强的相关性(R=0.75, p
Background-Despite the increasing interest in using knee cartilage volume as an outcome measure in studies of osteoarthritis (OA), it is unclear what components of knee cartilage will be most useful as markers of structure in the tibiofemoral (TF) joint.Objective-To compare the changes that occur in femoral and tibial cartilage volume in normal and osteoarthritic knees and how they relate to radiological grade.Methods-82 subjects (44 female, 38 male, age range 35-69 years) with a spectrum of radiological knee OA were examined. Each subject had femoral and tibial cartilage volume in the medial and lateral TF joint determined from T-1 weighted fat saturated magnetic resonance images of the knee. Radiological grade of OA was determined from standing knee radiographs.Results-There was strong correlation between femoral and tibial cartilage volume measured in both the medial (R=0.75, p