Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria.
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria.
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人类体内有大量不同的微生物，这些微生物受到许多因素的影响，包括年龄和遗传学，并反过来影响免疫状态。在eLife中，Knight及其同事对居住在皮肤、口腔和肠道中的微生物进行了全面调查，以确定与家庭成员和狗同居的影响。许多模式出现;例如，同一家庭的成员之间共享的微生物群比来自其他家庭的人共享的微生物群多，这种重叠对于皮肤微生物群来说是最大的。值得注意的是，狗的所有权导致人类之间更多的微生物群共享，狗和人类之间也有相当多的微生物群共享。年龄也有一定的作用，肠道微生物群的最大变化发生在婴儿早期的一个窗口内，但皮肤微生物群随着年龄的增长保持相对稳定。因此，共享的环境强烈影响微生物群的定植，这可能会潜在地影响免疫系统的“调整”。ZF eLife 2，e00458（2013）
Humans harbor a vast and diverse population of microbes that are affected by many factors, including age and genetics, and can in turn influence immunological status. In eLife, Knight and colleagues undertake a comprehensive survey of microbes that inhabit the skin, mouth and gut to determine the influence of cohabitation with family members and dogs. Many patterns emerge; for example, members of the same household share more microbiota with each other than with people from other households, and this overlap is greatest for the skin microbiota. Notably, dog ownership results in more sharing of microbiota among humans, and there is also considerable sharing of microbiota between dogs and humans. Age also has a role, with the greatest changes in gut microbiota occurring within a window during early infancy but the skin microbiota remaining relatively stable with age. A shared environment therefore strongly influences microbiota colonization and this might potentially feed forward into ‘tuning’of the immune system. ZF eLife 2, e00458 (2013)