Passive transfer of immunity of Mycobacterium avium in susceptible and resistant strains of mice.
Passive transfer of immunity of Mycobacterium avium in susceptible and resistant strains of mice.
复制标题
鸟分枝杆菌在易感和耐药菌株中的被动免疫转移。
DOI：
10.1111/j.1365-2249.1990.tb05299.x
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发表时间：
1990
影响因子：
4.6
通讯作者：
Collins,FM
中科院分区：
文献类型：
--
作者：
Stokes,RW;Collins,FM
自然易感小鼠 (C57BL/6) 感染 M. avium（Weybridge品系）产生了一群脾T细胞，将其转移到同基因受体小鼠中后，对随后的M的攻击接种物产生了显着的保护作用。鸟。来自天然抗性小鼠 (A/J) 的类似 T 细胞不能保护同基因受体小鼠。 M的成长。 aviumin 供体小鼠仅出现在 C57BL/6 品系中。 M 的复制。 aviumin 供体小鼠对于保护性 T 细胞的发育是必需的。大量杀死的分枝杆菌不会诱导免疫 T 细胞。此外。 A/J 小鼠接种了越来越多的 VivaM。 avium（仍然没有复制）未能发育出保护性 T 淋巴细胞。进一步的研究表明，M 中不存在保护性 T 细胞。 avium 感染的 A/J 小鼠，尽管获得了这些小鼠非特异性免疫的证据。此外，BCG（在 A/J 小鼠中逐渐生长）刺激了脾 T 细胞群，从而保护受体小鼠免受随后的 M 感染。结核。
Naturally susceptible mice (C57BL/6) infected withM. avium(strain Weybridge) developed a population of splenic T cells which, on transfer to syngeneic recipient mice, conferred significant protection against a subsequent challenge inoculum ofM. avium. Similar T cells from naturally resistant mice (A/J) did not protect syngeneic recipient mice. Growth ofM. aviumin donor mice only occurred in the C57BL/6 strain. Replication ofM. aviumin donor mice was necessary for the development of protective T cells. High numbers of killed mycobacterium did not induce immune T cells. In addition. A/J mice inoculated with increasing numbers of viableM. avium(which still did not replicate) failed to develop protective T lymphocytes. Further studies indicated that no protective T cells were present in theM. avium‐infected A/J mouse, although evidence for non‐specific immunity in these mice was obtained. In addition, BCG (which grows progressively in A/J mice) stimulated a population of splenic T cells which protected recipient mice from subsequent infection withM. tuberculosis.