Micronutrients and host resistance to viral infection
Micronutrients and host resistance to viral infection
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DOI：
10.1017/s0029665100000823
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发表时间：
2000-11-01
影响因子：
7
通讯作者：
Matthews, CC
中科院分区：
文献类型：
--
作者：
Beck, MA;Matthews, CC
我们实验室以前的工作表明，病毒可以在缺乏硒的宿主中发生快速突变，导致通常无毒的病毒由于基因组变化而获得毒力。一旦这些突变发生，即使是硒营养充足的宿主也会对新的强毒病毒易感。硒缺乏对宿主的免疫反应有什么影响？柯萨奇病毒心肌炎株感染可诱导心脏组织的炎症反应。正是这种免疫反应引起了心脏损伤，而不是直接对心脏组织的病毒作用。趋化因子是在感染期间分泌的化学引诱物分子，以将免疫细胞吸引到损伤部位，并且已发现其对于柯萨奇病毒诱导的心肌炎的发展是重要的。我们发现，硒缺乏影响趋化因子单核细胞趋化蛋白-1的mRNA的表达，这可能有影响心肌炎的发展，在硒缺乏的主机。干扰素-γ的mRNA表达也大大减少在硒缺乏的动物。因此，硒的缺乏可以对宿主以及病毒本身产生深远的影响。硒缺乏动物的免疫应答的改变如何影响致病基因型的发展仍有待回答。
Previous work in our laboratory demonstrated that a virus could undergo rapid mutation in a host deficient in Se, leading to a normally avirulent virus acquiring virulence due to genome changes. Once these mutations occur, even a host with adequate Se-nutriture is susceptible to the newly virulent virus. What influence does the deficiency in Se have on the immune response of the host? Infection with myocarditic strains of coxsackievirus induces an inflammatory response in the cardiac tissue. It is this immune response that induces the heart damage, rather than direct viral effects on the heart tissue. Chemokines are chemo-attractant molecules that are secreted during an infection in order to attract immune cells to the site of the injury, and have been found to be important for the development of coxsackievirus-induced myocarditis. We found that a deficiency in Se influences the expression of mRNA for the chemokine monocyte chemo-attractant protein-1, which may have implications for the development of myocarditis in the Se-deficient host. Expression of mRNA for interferon-gamma was also greatly decreased in the Se-deficient animal. Thus, a deficiency in Se can have profound effects on the host as well as on the virus itself. How the alteration of the immune response of the Se-deficient animal affects the development of the virulent genotype remains to be answered.