Personality traits and personality disorders in early onset versus late onset major depression
Personality traits and personality disorders in early onset versus late onset major depression
复制标题
DOI：
10.1016/s0165-0327(02)00028-9
复制
发表时间：
2003-06-01
影响因子：
6.6
通讯作者：
Ekselius, L
中科院分区：
文献类型：
--
作者：
Ramklint, M;Ekselius, L
背景：我们的目的是确定某些人格障碍和/或人格特征与早发性重性抑郁症之间的关系。研究方法：共有400名抑郁症的初级保健患者进行了评估人格障碍使用的SCID屏幕和人格特质使用卡罗林斯卡人格量表（KSP）问卷。早发定义为26岁之前首次发作。在调整性别、年龄和既往发作次数后，进行逻辑回归以揭示关系。结果：两组有相似的严重程度，目前的疾病确定的蒙哥马利-Angstromsberg抑郁量表。那些早发的人表现出更衰弱的病程，表现为更多的抑郁发作和既往住院史，尽管他们年龄较小。早发也是回避型、边缘型和偏执型人格障碍的独立预测因子。它还预测了KSP量表上精神焦虑、精神衰弱、肌肉紧张、怀疑和易怒的分数增加，以及社交能力下降。局限性：评估作为自我评估进行，受试者在评估时有叠加的重度抑郁发作，个体亚组不合格。结论：早发性抑郁症是人格病理和异常人格特征的预测因子。更好地理解遗传学和环境之间的相互作用，这一现象的基础将有助于改善患病个体的长期过程。(C)2002 Elsevier Science B. V.保留所有权利。
Background: We aimed to determine the relationship between certain personality disorders and/or personality traits and early onset major depression. Methods: A total of 400 depressed primary care patients were assessed for personality disorders using the SCID screen and for personality traits using the Karolinska Scales of Personality (KSP) questionnaire. Early onset was defined as onset of the first episode before the age of 26. Logistic regressions were performed to reveal relationships after adjustment for sex, age and number of previous episodes. Results: Both groups had a similar severity of current illness determined by the Montgomery-Angstromsberg Depression Rating Scale. Those with an early onset presented with a more debilitating course, seen in the form of more depressive episodes and previous hospitalisations in spite of their younger age. Early onset was also an independent predictor for avoidant, borderline and paranoid personality disorders. It also predicted increased scores on the KSP scales Psychic anxiety, Psychasthenia, Muscular tension, Suspicion and Irritability, and decreased Socialisation. Limitations: The evaluation was performed as a self-assessment, subjects had a superimposed major depressive episode when assessed, and subgroups of individuals were not eligible. Conclusions: Early onset major depression is a predictor for personality pathology and deviant personality traits. A better understanding of the interplay between genetics and environment that underlies this phenomenon will help to improve the long-term course in afflicted individuals. (C) 2002 Elsevier Science B.V. All rights reserved.