Lipocalin-type prostaglandin D synthase (beta-trace) in cerebrospinal fluid: a useful marker for the diagnosis of normal pressure hydrocephalus
Lipocalin-type prostaglandin D synthase (beta-trace) in cerebrospinal fluid: a useful marker for the diagnosis of normal pressure hydrocephalus
复制标题
DOI：
10.1016/j.neures.2003.08.009
复制
发表时间：
2003-12-01
影响因子：
2.9
通讯作者：
Urade, Y
中科院分区：
文献类型：
--
作者：
Mase, M;Yamada, K;Urade, Y
脂质运载蛋白型前列腺素D合酶(PGDS)被认为主要在软脑膜中产生并分泌到脑脊液(CSF)中。我们发现正常压力脑积水 (NPH) 患者脑脊液中的 PGDS 水平（8.99 +/- 2.59 mug/ml，平均值 +/- S.D.，n = 14）显着低于对照组（15.29 +/- 5.17，n = 14，P < 0.0001）和其他痴呆组（19.14 +/- 4.34，n = 14）的水平7，P = 0.0003）。因此，脑脊液中的 PGDS 水平是鉴别 NPH 与其他痴呆疾病的有用标志。 (C) 2003 Elsevier Ireland Ltd 和日本神经科学学会。版权所有。
Lipocalin-type prostaglandin D synthase (PGDS) is considered to be mainly produced in the leptomeninges and secreted into cerebrospinal fluid (CSF). We found PGDS levels in CSF of patients with normal pressure hydrocephalus (NPH) (8.99 +/- 2.59 mug/ml, mean +/- S.D., n = 14) to be significantly lower than levels in a control (15.29 +/- 5.17, n = 14, P < 0.0001) and other dementia group (19.14 +/- 4.34, n = 7, P = 0.0003). Thus, PGDS level in CSF is a useful marker for the differential diagnosis of NPH from other diseases with dementia. (C) 2003 Elsevier Ireland Ltd and The Japan Neuroscience Society. All rights reserved.