Improved Stability and Photothermal Performance of Polydopamine-Modified Fe3O4Nanocomposites for Highly Efficient Magnetic Resonance Imaging-Guided Photothermal Therapy
Improved Stability and Photothermal Performance of Polydopamine-Modified Fe3O4Nanocomposites for Highly Efficient Magnetic Resonance Imaging-Guided Photothermal Therapy
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DOI：
10.1002/smll.202003969
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发表时间：
2020-10-14
期刊：
影响因子：
13.3
通讯作者：
Liu, Jianhua
中科院分区：
文献类型：
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作者：
Li, Bo;Gong, Tingting;Liu, Jianhua
磁性纳米材料是一类很有前途的磁共振成像（MRI）造影剂。然而，其稳定性差和弛豫率低是阻碍其临床应用的主要挑战。在这项研究中，基于聚多巴胺修饰的Fe 3 O 4（Fe3O4@PDA）纳米复合材料的磁性治疗诊断剂被制造用于MRI引导的光热疗法（PTT）癌症治疗。其337.8 mM（-1）s（-1）的高横向弛豫率使这些Fe3O4@PDA纳米复合材料成为用于癌症诊断和图像引导癌症治疗的有希望的T-2加权MRI造影剂。由于聚多巴胺（PDA）具有良好的光热效应，采用PTT法将4 T1荷瘤小鼠的肿瘤完全切除。最重要的是，PDA外壳还提高了Fe3O4@PDA纳米复合材料的稳定性，这有助于其在MRI和PTT应用中的优异长期性能。这些纳米复合材料具有良好的稳定性、高的T（2）弛豫率、稳定的生物相容性和令人满意的治疗效果，这使得Fe3O4@PDA纳米复合材料在癌症治疗诊断中具有巨大的应用潜力。
Magnetic nanomaterials are a promising class of contrast agents for magnetic resonance imaging (MRI). However, their poor stability and low relaxivity are major challenges hindering their clinical applications. In this study, magnetic theranostic nanoagents based on polydopamine-modified Fe3O4(Fe3O4@PDA) nanocomposites are fabricated for MRI-guided photothermal therapy (PTT) cancer treatments. Their high transverse relaxivity of 337.8 mM(-1)s(-1)makes these Fe3O4@PDA nanocomposites a promising T-2-weighted MRI contrast agent for cancer diagnosis and image-guided cancer therapy. Due to the good photothermal effect of polydopamine (PDA), the tumors of 4T1 tumor-bearing mice are completely excised by PTT. Most importantly, the PDA shell also improves the stability of the Fe3O4@PDA nanocomposites, which contributes to their excellent, long-term performance in MRI and PTT applications. Their good stability, high T(2)relaxivity, robust biocompatibility, and satisfactory treatment effect give these Fe3O4@PDA nanocomposites great potential for use in cancer theranostics.