Synthesis of aryl anti-vicinal diamines via aza-Brook rearrangement-initiated nucleophilic addition of α-silylamines to imines.
Synthesis of aryl anti-vicinal diamines via aza-Brook rearrangement-initiated nucleophilic addition of α-silylamines to imines.
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DOI：
10.1021/acs.joc.5b00255
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发表时间：
2015-03
期刊：
影响因子：
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通讯作者：
Chao-Yang Lin;Zhao Sun;Yan-Jun Xu;Chong-Dao Lu
中科院分区：
文献类型：
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作者：
Chao-Yang Lin;Zhao Sun;Yan-Jun Xu;Chong-Dao Lu
本文报道了一种由氮杂-布鲁克重排引发的α-硅胺与亚胺的亲核加成反应合成邻二胺的有效方法。各种对称和不对称的芳基二胺衍生物的制备在中等到高的产率与高的反/顺非对映选择性。
An efficient protocol is described for the synthesis of vicinal diamines via aza-Brook rearrangement-initiated nucleophilic addition of α-silylamines to imines. Various symmetrical and unsymmetrical aryl diamine derivatives were prepared in moderate to high yields with high anti/syn diastereoselectivity.