Glaucoma and vasospasm
Glaucoma and vasospasm
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DOI：
10.1136/bjo.82.8.862
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发表时间：
1998-08-01
影响因子：
4.1
通讯作者：
Drance, SM
中科院分区：
文献类型：
--
作者：
Broadway, DC;Drance, SM
目的/背景-研究具有四种先前描述的不同椎间盘外观的青光眼患者的血管活性，这些椎间盘外观可能代表原发性开角型青光眼亚组。方法：我们选择了四种类型的青光眼视盘患者，即局灶性缺血性、近视性青光眼、老年性青光眼和广泛性视杯增大的患者。A.从患者中采集详细的眼科、全身、药物和吸烟史，此外，还用激光多普勒血流计评估外周血管痉挛。使用方差分析、Student t检验、Pearson卡方检验、Fisher精确检验以及斯皮尔曼和Pearson相关性检验来评估组间差异。结果38例局灶性缺血性患者、37例近视性青光眼患者、24例老年性硬化症患者和24例以泛杯扩大为特征的椎间盘患者符合选择标准。局灶性椎间盘缺血患者组中女性较多（66% vs其他三组32%-50%; p=0.01），血管痉挛（63% vs 25%-49%; p=0.01）、偏头痛（32% vs 8%-19%; p=0.02）和感冒的患病率较高。四肢（66%对17%-30%; p=0.00003），老年椎间盘突出患者组的全身性心血管疾病患病率较高，（58%对比其他三组的21%-30%; p=0.01）和甲状腺疾病（21%对比0%-8%; p=0.01），尽管他们的平均年龄更大（76岁对比55-55岁; p
Aims/background- To study the study the vasoactivity of glaucoma patients with four previously described and distinct disc appearances potentially representative of primary open angle glaucoma subgroups. Methods-Patients with pure examples of four glaucomatous optic disc types-focal ischaemic, myopic glaucomatous, senile sclerotic, and those with generalised cup enlargement, were selected. A. detailed ophthalmic, systemic, drug, and smoking history was taken from the patients who, in addition, underwent assessment of peripheral vasospasm with a laser Doppler flowmeter. Differences between the groups were evaluated using an analysis of variance, Student's t test, Pearson's chi(2) rest, Fisher's exact test together with Spearman's and Pearson's correlation tests.Results-38 patients with focal ischaemic, 37 with myopic glaucomatous, 24 with senile sclerotic, and 24 with discs characterised by generalised cup enlargement met the selection criteria. The group of patients with focal ischaemic discs contained more women (66% versus 32%-50% In the other three groups; p=0.01) and had a higher prevalence of vasospasm (63% versus 25%-49%; p=0.01), migraine (32% versus 8%-19%; p=0.02), and cold. extremities (66% versus 17%-30%; p=0.00003), The group of patients with senile sclerotic discs had a higher prevalence of systemic cardiovascular disease (58% versus 21%-30% in the other three groups; p=0.01) and thyroid disease (21% cf 0%-8%; p=0.01) and although their mean age was greater (76 years cf 55-55 years; p