PRENATAL AND PERINATAL-DEVELOPMENT OF THE SOMATOSTATIN-IMMUNOREACTIVE NEURONS IN THE HUMAN PREFRONTAL CORTEX
PRENATAL AND PERINATAL-DEVELOPMENT OF THE SOMATOSTATIN-IMMUNOREACTIVE NEURONS IN THE HUMAN PREFRONTAL CORTEX
复制标题
DOI：
10.1016/0304-3940(91)90082-5
复制
发表时间：
1991-04-01
影响因子：
2.5
通讯作者：
DELALLE, I
中科院分区：
文献类型：
--
作者：
KOSTOVIC, I;STEFULJFUCIC, A;DELALLE, I
最早的生长抑素免疫反应（SS-Ir）人类胎儿额叶皮质核周出现在妊娠22周的短暂亚板区。妊娠32周左右，基底带和皮质板交界面处的SS-Ir神经元数量增加。新生皮层显示SS-Ir神经元总数的减少与SS-Ir神经元在浅层的出现平行。综上所述，底板神经元是皮层中最早的肽能活性的来源。此外，肽能神经元的分布和密度在围产期发育过程中发生了重大的重组。
The earliest somatostatin-immunoreactive (SS-Ir) perikarya of the human fetal frontal cortex appear in the transient subplate zone at 22 weeks of gestation. Around 32 weeks of gestation there is an increase in the number of SS-Ir neurons at the interface between the subplate zone and the cortical plate. The newborn cortex shows decline in the overall number of SS-Ir neurons parallel to the appearance of SS-Ir neurons in the superficial layers. In conclusion, the subplate neurons are the source of the earliest peptidergic activity in the cortex. Furthermore, the distribution and density of peptidergic neurons undergo significant reorganization during the perinatal development.