High folic acid or folate combined with low vitamin B-12 status: potential but inconsistent association with cognitive function in a nationally representative cross-sectional sample of US older adults participating in the NHANES
High folic acid or folate combined with low vitamin B-12 status: potential but inconsistent association with cognitive function in a nationally representative cross-sectional sample of US older adults participating in the NHANES
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DOI：
10.1093/ajcn/nqaa239
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发表时间：
2020-12-01
影响因子：
7.1
通讯作者：
Miller, Joshua W.
中科院分区：
文献类型：
--
作者：
Bailey, Regan L.;Jun, Shinyoung;Miller, Joshua W.
背景：当高叶酸暴露与低维生素 B-12 状态相结合时，可能存在与认知功能受损相关的潜在安全问题。目的：我们旨在研究高叶酸和低维生素 B-12 状态共存与认知功能的关系。利用“高”叶酸状态的各种定义。方法：分析了 2011-2014 年 NHANES 中老年人（≥ 60 岁；n = 2420）的横截面数据。高叶酸状态定义为未代谢血清叶酸 (UMFA) > 1 nmol/L 或血清总叶酸 > 74.1 nmol/L，低维生素 B-12 状态定义为甲基丙二酸 > 271 nmol/L 或血清维生素 B-12 < 150 pmol/L。逻辑回归模型估计了 4 项认知测试中的 1 项得分较低的 OR：数字符号替换测试 (DSST)。建立阿尔茨海默病延迟回忆 (CERAD-DR) 和单词学习测试以及动物流利度测试 (AF) 注册表的联盟。 结果：观察到与 DSST 得分低相关的显着交互作用（
Background: Potential safety concerns relative to impaired cognitive function may exist when high folic acid exposures are combined with low vitamin B-12 status.Objectives: We aimed to examine the relation of the coexistence of high folate and low vitamin B-12 status with cognitive function. utilizing various definitions of "high" folate status.Methods: Cross-sectional data from older adults (>= 60 y; n = 2420) from the 2011-2014 NHANES were analyzed. High folate status wa defined as unmetabolized serum folic acid (UMFA) > 1 nmol/L or serum total folate > 74.1 nmol/L, and low vitamin B-12 status as methylmalonic acid > 271 nmol/L or scrum vitamin B-12 < 150 pmol/L. Logistic regression models estimated ORs of scoring low on 1 of 4 cognitive tests: the Digit Symbol Substitution Test (DSST). the Consortium to Establish a Registry for Alzheimer's Disease Delayed Recall (CERAD-DR) and Word Learning tests, and the Animal Fluency test (AF).Results: A significant interaction was observed relative to scoring low on the DSST (