USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS.
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS.
复制标题
USP18 通过促进 MAVS 的 K63 连接多聚泛素化积极调节先天抗病毒免疫
DOI：
10.1038/s41467-021-23219-4
复制
发表时间：
2021-05-20
影响因子：
16.6
通讯作者：
Gao C
中科院分区：
文献类型：
--
作者：
Hou J;Han L;Zhao Z;Liu H;Zhang L;Ma C;Yi F;Liu B;Zheng Y;Gao C
Activation of MAVS, an adaptor molecule in Rig-I-like receptor (RLR) signaling, is indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS activation are not completely understood. Ubiquitination has a central function in regulating the activity of MAVS. Here, we demonstrate that a mitochondria-localized deubiquitinase USP18 specifically interacts with MAVS, promotes K63-linked polyubiquitination and subsequent aggregation of MAVS. USP18 upregulates the expression and production of type I interferon following infection with Sendai virus (SeV) or Encephalomyocarditis virus (EMCV). Mice with a deficiency of USP18 are more susceptible to RNA virus infection. USP18 functions as a scaffold protein to facilitate the re-localization of TRIM31 and enhances the interaction between TRIM31 and MAVS in mitochondria. Our results indicate that USP18 functions as a post-translational modulator of MAVS-mediated antiviral signaling.
登录
查看更多内容
DOI：
10.1084/jem.20151529
发表时间：
2016-06-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Meuwissen ME;Schot R;Buta S;Oudesluijs G;Tinschert S;Speer SD;Li Z;van Unen L;Heijsman D;Goldmann T;Lequin MH;Kros JM;Stam W;Hermann M;Willemsen R;Brouwer RW;Van IJcken WF;Martin-Fernandez M;de Coo I;Dudink J;de Vries FA;Bertoli Avella A;Prinz M;Crow YJ;Verheijen FW;Pellegrini S;Bogunovic D;Mancini GM
通讯作者：
Mancini GM
FAF1 通过抑制 MAVS 调节抗病毒免疫，但在病毒感染时被磷酸化拮抗
影响因子：
30.3
作者：
Dai, Tong;Wu, Liming;Zhang, Long
通讯作者：
Zhang, Long
影响因子：
158.5
作者：
Alsohime, Fahad;Martin-Fernandez, Marta;Alangari, Abdullah A.
通讯作者：
Alangari, Abdullah A.
影响因子：
4.4
作者：
Kim, KI;Malakhova, OA;Zhang, DE
通讯作者：
Zhang, DE
MAVS 的多个截短亚型可防止其在抗病毒先天免疫信号中自发聚集。
影响因子：
16.6
作者：
Qi N;Shi Y;Zhang R;Zhu W;Yuan B;Li X;Wang C;Zhang X;Hou F
通讯作者：
Hou F