Increased virulence of rabbit haemorrhagic disease virus associated with genetic resistance in wild Australian rabbits (Oryctolagus cuniculus).
Increased virulence of rabbit haemorrhagic disease virus associated with genetic resistance in wild Australian rabbits (Oryctolagus cuniculus).
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DOI：
10.1016/j.virol.2014.06.037
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发表时间：
2014-09
期刊：
影响因子：
3.7
通讯作者：
Strive T
中科院分区：
文献类型：
--
作者：
Elsworth P;Cooke BD;Kovaliski J;Sinclair R;Holmes EC;Strive T
粘液瘤病毒(MYXV)和兔出血症病毒(RHDV)在澳大利亚的释放，为控制过度繁殖的兔子提供了一个独特的机会，为研究新出现的病原体的最初传播和建立，以及它们与哺乳动物宿主的共同进化提供了独特的机会。与MYXV不同的是，RHDV在引入后不久就会衰减，但没有观察到RHDV的快速衰减。通过研究最近在单个现场分离的RHDV毒力的变化，我们首次表明，RHDV的毒力随着时间的推移而增加，可能是因为选择克服了澳大利亚野兔正在形成的遗传抗性。高毒力似乎也受到青睐，因为兔子的身体，而不是患病的动物，可能是昆虫机械传播的来源。这些发现不仅有助于阐明兔和RHDV之间的共同进化相互作用，而且揭示了影响毒力进化的一些关键因素。
The release of myxoma virus (MYXV) and Rabbit Haemorrhagic Disease Virus (RHDV) in Australia with the aim of controlling overabundant rabbits has provided a unique opportunity to study the initial spread and establishment of emerging pathogens, as well as their co-evolution with their mammalian hosts. In contrast to MYXV, which attenuated shortly after its introduction, rapid attenuation of RHDV has not been observed. By studying the change in virulence of recent field isolates at a single field site we show, for the first time, that RHDV virulence has increased through time, likely because of selection to overcome developing genetic resistance in Australian wild rabbits. High virulence also appears to be favoured as rabbit carcasses, rather than diseased animals, are the likely source of mechanical insect transmission. These findings not only help elucidate the co-evolutionary interaction between rabbits and RHDV, but reveal some of the key factors shaping virulence evolution.