BRAIN ENDOTHELIAL-CELL INFECTION IN CHILDREN WITH ACUTE FATAL MEASLES
BRAIN ENDOTHELIAL-CELL INFECTION IN CHILDREN WITH ACUTE FATAL MEASLES
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DOI：
10.1172/jci118306
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发表时间：
1995-11-01
影响因子：
15.9
通讯作者：
GRIFFIN, DE
中科院分区：
文献类型：
--
作者：
ESOLEN, LM;TAKAHASHI, K;GRIFFIN, DE
神经系统疾病是麻疹的重要并发症，病毒感染中枢神经系统的作用以及病毒进入的途径尚不清楚。研究人员对五例在皮疹出现后 3-10 天死于严重急性麻疹的个体进行尸检，以寻找病毒累及中枢神经系统的证据。在所有病例中，原位杂交和 RT-PCR 原位杂交技术均显示内皮细胞感染，抗铁蛋白抗体的免疫过氧化物酶染色显示反应性小胶质细胞增生。这些数据表明，在急性致命性麻疹期间，大脑中的内皮细胞经常被感染。该感染部位可能为随后发展为亚急性硬化性全脑炎或麻疹包涵体脑炎的个体提供病毒的进入门户，并成为麻疹后脑脊髓炎免疫反应的目标。
Neurologic diseases are important complications of measles, The role of virus infection of the central nervous system as well as the route of virus entry has been unclear. Five autopsied cases of individuals who died with severe acute measles 3-10 d after the onset of the rash were studied for evidence of viral involvement of the central nervous system. In all cases, in situ hybridization and RT-PCR in situ hybridization techniques showed endothelial cell infection, Immunoperoxidase staining with an anti-ferritin antibody revealed a reactive microgliosis. These data suggest that endothelial cells in the brain are frequently infected during acute fatal measles, This site of infection may provide a portal of entry for virus in individuals who subsequently develop subacute sclerosing panencephalitis or measles inclusion body encephalitis and a target for immunologic reactions in postmeasles encephalomyelitis.