Natural thymocytotoxic autoantibodies in autoimmune and normal mice.
Natural thymocytotoxic autoantibodies in autoimmune and normal mice.
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自身免疫小鼠和正常小鼠中的天然胸腺细胞毒性自身抗体。
DOI：
10.4049/jimmunol.122.6.2272
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发表时间：
1979
影响因子：
4.4
通讯作者：
Frank J. Dixon
中科院分区：
文献类型：
--
作者：
Robert A. Eisenberg;Argyrios N. Theofilopoulos;Brian S. Andrews;C. Peters;Lee T. Thor;Frank J. Dixon
在所有小鼠品系中均发现天然胸腺细胞毒自身抗体。在表现出类似人类系统性红斑狼疮（SLE）的自身免疫性综合征的毒株中，NZB和NZBxNZW具有高水平的NTA， BXSB具有中等水平，MRL/1和MRL/n具有非常低的水平。此外，一些正常菌株有高水平，有时甚至高于自身免疫菌株。NTA主要是IgM，存在于自身免疫小鼠品系的低温沉淀中，但不集中。在大多数菌株中，它们被指向胸腺细胞和大脑共享的抗原。未能在所有自身免疫小鼠品系中发现高水平的NTA，以及在一些正常品系中发现非常高的水平，使得这种自身抗体不太可能是所有小鼠SLE的根本病因。
Natural thymocytotoxic autoantibodies (NTA) were found in all mouse strains. Among those strains that show autoimmune syndromes resembling human systemic lupus erythematosus (SLE), the NZB and NZBxNZW had high levels of NTA, the BXSB had moderate levels, and the MRL/1 and MRL/n had very low levels. In addition, some normal strains had high levels, sometimes even higher than the autoimmune strains. The NTA were mostly IgM and were present, but not concentrated, in the cryoprecipitates of teh autoimmune mouse strains. In most strains, they were directed toward an antigen shared by thymocytes and brain. The failure to find high levels of NTA in all autoimmune mouse strains, as well as the finding of very high levels in some normal strains, make it unlikely that such auto-antibodies are a fundametnal etiologic factor in all murine SLE.