Role of H1 linker histones in mammalian development and stem cell differentiation.
Role of H1 linker histones in mammalian development and stem cell differentiation.
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DOI：
10.1016/j.bbagrm.2015.12.002
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Fan Y
中科院分区：
文献类型：
--
作者：
Pan C;Fan Y
H1接头组蛋白是促进高级染色质结构形成的关键染色质结构蛋白。H1家族是组蛋白中最具异质性的一组，在哺乳动物中有11种非等位基因H1变体。H1变体在其生物化学性质上不同，并且彼此表现出显着的序列差异，但它们中的大多数在从小鼠到人类的进化过程中是高度保守的。H1变体在发育过程中受到差异调节，并且它们的细胞组成在胚胎发生、配子发生、组织成熟和细胞分化中发生显著变化。作为一个组，H1组蛋白是小鼠发育和适当的干细胞分化所必需的。在这里，我们总结了我们目前的知识H1变体在哺乳动物发育和干细胞分化的表达和功能。它们的多样性，序列保守性，复杂的表达和独特的功能表明，H1介导染色质重编程，并有助于在哺乳动物基因组中的染色质结构和基因表达的大的变化和复杂性。
H1 linker histones are key chromatin architectural proteins facilitating the formation of higher order chromatin structures. The H1 family constitutes the most heterogeneous group of histone proteins, with eleven non-allelic H1 variants in mammals. H1 variants differ in their biochemical properties and exhibit significant sequence divergence from one another, yet most of them are highly conserved during evolution from mouse to human. H1 variants are differentially regulated during development and their cellular compositions undergo dramatic changes in embryogenesis, gametogenesis, tissue maturation and cellular differentiation. As a group, H1 histones are essential for mouse development and proper stem cell differentiation. Here we summarize our current knowledge on the expression and functions of H1 variants in mammalian development and stem cell differentiation. Their diversity, sequence conservation, complex expression and distinct functions suggest that H1s mediate chromatin reprogramming and contribute to the large variations and complexity of chromatin structure and gene expression in the mammalian genome.