A study of the interleukin-1 gene cluster polymorphisms and inflammatory external root resorption in replanted permanent teeth.
A study of the interleukin-1 gene cluster polymorphisms and inflammatory external root resorption in replanted permanent teeth.
复制标题
白细胞介素1基因簇多态性与再植恒牙炎症性外根吸收的研究。
DOI：
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发表时间：
2015
影响因子：
5
通讯作者：
W. Dutra
中科院分区：
文献类型：
--
作者：
J. V. Bastos;M. Côrtes;J. F. C. Silva;E. M. Goulart;E. Colosimo;R. Gomez;W. Dutra
目的
目的探讨白细胞介素1基因簇（IL 1）单核苷酸多态性（SNP）是否与撕脱恒牙再植后炎性外根吸收（IERR）的发生及严重程度相关。
方法
本文对146例182颗再植恒牙在根管治疗开始时的IERR指数进行了X线评价。从颊粘膜细胞提取DNA，并使用基于TaqMan探针的测定法对SNP IL 1A-889 C/T（rs 180058）、IL 1B +3954 C/T（rs 1143634）和IL 1 RN +2018 C/T（rs 419598）进行基因分型。将牙齿分为两类：无至轻度（指数≤ 4）和中至重度（指数> 4）IERR。使用GEE模型（广义估计方程）检测IL 1基因簇中的遗传变异对IERR发生和扩展的影响。患者受伤时的年龄、牙髓切除术的时间、牙槽期外和撕脱牙的储存条件被列为可能的混杂因素。
结果
IL 1A-889 C/T、IL 1B +3954 C/T（rs 1143634）和IL 1 RN +2018 C/T（rs 419598）与IERR指数无相关性。牙髓切除术的时机（OR 3.5 IC 95% 2.0-6.2 P < 0.001）和患者创伤时的年龄（OR 0.29 IC 95% 0.12-0.67 P = 0.004）显著影响发生严重IERR的风险。
结论
虽然牙髓切除术的时间和患者的年龄在创伤的时刻被证实是重要的风险因素，白细胞介素1基因簇内的SNPs并没有影响恒牙再植后IERR的易感性。
AIM
To investigate whether single nucleotide polymorphisms (SNPs) within the interleukin-1 gene cluster (IL1) are associated with the occurrence and severity of inflammatory external root resorption (IERR) after replantation of avulsed permanent teeth.
METHODOLOGY
Indexes of IERR were radiographically assessed in 182 mature replanted permanent teeth from 146 patients at the onset of endodontic therapy. DNA was extracted from buccal mucosa cells and genotyped using TaqMan probes-based assays for the SNPs IL1A -889C/T (rs 180058), IL1B +3954C/T (rs1143634) and IL1RN +2018C/T (rs419598). Teeth were grouped into two categories: IERR absent to mild (indexes ≤ 4) and moderate to severe IERR (indexes > 4). Genetic variations in the IL1 gene cluster were tested for their effect on the occurrence and extension of IERR using the GEE model (generalized estimation equation). Patient's age at the moment of injury, timing of pulpectomy, extra-alveolar period and storage condition of the avulsed teeth was included as possible confounders.
RESULTS
No association was found between SNPs IL1A -889C/T, IL1B +3954C/T (rs1143634) and IL1RN +2018C/T (rs419598) and IERR indexes. Timing of pulpectomy (OR 3.5 IC 95% 2.0-6.2 P < 0.001) and patient's age at the moment of trauma (OR 0.29 IC 95% 0.12-0.67 P = 0.004) significantly affected the risk of developing severe IERR.
CONCLUSIONS
While timing of pulpectomy and patient's age at the moment of trauma were confirmed as important risk factors, SNPs within the IL1 gene cluster did not affect the susceptibility for IERR after replantation of permanent teeth.
影响因子：
20.3
作者：
C. Dinarello
通讯作者：
C. Dinarello
影响因子：
4.2
作者：
Morsani JM;Aminoshariae A;Han YW;Montagnese TA;Mickel A
通讯作者：
Mickel A
影响因子：
3.1
作者：
Hartsfield JK Jr
通讯作者：
Hartsfield JK Jr