Central Corneal Thickness Variances Among Different Asian Ethnicities in Glaucoma and Nonglaucoma Patients
Central Corneal Thickness Variances Among Different Asian Ethnicities in Glaucoma and Nonglaucoma Patients
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DOI：
10.1097/ijg.0000000000001180
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发表时间：
2019-03-01
影响因子：
2
通讯作者：
Lin, Shan
中科院分区：
文献类型：
--
作者：
Badr, Mai;Solano, Marisse Masis;Lin, Shan
目的：比较不同民族特别是亚洲亚民族青光眼的中央角膜厚度（CCT）与光学低相干反射技术诊断青光眼的差异。方法：回顾性研究2011年至2017年加州大学旧金山分校贝克曼视力中心就诊的929例患者1512只眼，采用Lenstar测量CCT等生物特征参数，为期6年。患者分为非裔美国人、高加索人、西班牙人、太平洋岛民和亚洲人。亚洲人进一步细分为中国人、越南人、韩国人、菲律宾人和日本人。结果：2011年至2017年，Lenstar测量了1356例患者的CCT，纳入了929例患者的1512只眼睛。研究人群包括462名白种人（52.96%）、60名非洲裔美国人（6.46%）、92名西班牙裔美国人（9.9%）、32名太平洋岛民（3.44%）、130名中国人（13.99%）、52名菲律宾人（5.6%）、37名越南人（3.98%）、34名韩国人（3.66%）和30名日本人（3.23%）。非洲裔美国人的CCT最薄，平均为518.62 +/- 40.3，其次是亚洲人，平均为539.29 +/- 34.1。在亚洲研究样本中，中国人的CCT最薄，平均值为537.66 +/- 32.5。CCT根据年龄、性别、青光眼诊断、糖尿病状况和前列腺素类似物使用情况进行调整。结论：光学低相干反射法可以测量CCT，是一种应用广泛的技术。我们的研究证实，非洲裔美国人的眼角膜最薄，其次是亚洲人。在后一组中，相对较薄的CCT可能部分解释了他们的高正常眼压青光眼发生率。
Objective: To compare the central corneal thickness (CCT) between different ethnicities and particularly Asian subethnic groups that may contribute to the different glaucoma diagnoses using the optical low-coherence reflectometry technique. Methods: A retrospective study of 6 years including 1512 eyes of 929 patients of the Beckman vision center, University of California, San Francisco from 2011 to 2017 had their biometric parameters, including CCT, measured with the Lenstar. Patients were categorized into African Americans, Caucasians, Hispanics, Pacific Islanders, and Asians. Asians were further subcategorized into Chinese, Vietnamese, Koreans, Filipinos, and Japanese. Results: Among 1356 patients who had their CCT measured by Lenstar from 2011 to 2017, 1512 eyes of 929 patients were included. The study population included 462 Caucasians (52.96%), 60 African Americans (6.46%), 92 Hispanics (9.9%), 32 Pacific Islanders (3.44%), 130 Chinese (13.99%), 52 Filipinos (5.6%), 37 Vietnamese (3.98%), 34 Koreans (3.66%), and 30 Japanese (3.23%). African Americans had the thinnest CCT with a mean of 518.62 +/- 40.3 followed by Asians with a mean of 539.29 +/- 34.1. Among the Asian study sample, the Chinese had the thinnest CCT with a mean of 537.66 +/- 32.5. CCT was adjusted for age, sex, glaucoma diagnosis, diabetes status, and prostaglandin analogs use for >12 months. Conclusions: Optical low-coherence reflectometry is a widely used technology, which can measure CCT. Our study confirms that African Americans have the thinnest corneas followed by Asians. In the latter group, relatively thin CCT may partly explain their high rates of normal-tension glaucoma.