Real-time perfusion imaging with low mechanical index pulse inversion Doppler imaging
Real-time perfusion imaging with low mechanical index pulse inversion Doppler imaging
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DOI：
10.1016/s0735-1097(00)01204-3
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发表时间：
2001-03-01
影响因子：
24
通讯作者：
O'Leary, E
中科院分区：
文献类型：
--
作者：
Porter, TR;Xie, F;O'Leary, E
目的 我们试图确定脉冲反转多普勒 (PID) 成像在多巴酚丁胺负荷超声心动图期间检测心肌灌注缺陷的成功率。 背景 通过以低机械指数传输多个交替极性 (PID) 脉冲，可以使用实时帧速率检测静脉注射微泡引起的心肌对比增强。 方法 在多巴酚丁胺负荷超声心动图期间，通过使用静脉注射器对 117 名患者进行脉冲反转多普勒成像。全氟化碳填充的白蛋白-Optison：n = 98）或脂质体-（定义：n = 19）封装微泡的推注，机械指数为50%。 结果 在所有患者注射造影剂之前，心肌几乎没有信号。在多巴酚丁胺负荷超声心动图检查期间，117 名患者中的 114 名患者在帧率高达 25 Hz 时，至少在一个冠状动脉区域观察到峰值应力时明亮的心肌混浊。在至少一根血管狭窄 >50% 的所有 30 名患者中均观察到峰值应力时的区域心肌造影缺陷（13 名患者为单血管疾病，17 名患者为多血管疾病）。在 17 个直径狭窄 >50% 的区域中观察到对比缺陷，这些区域在峰值应力下具有正常的室壁运动。 QA 和心肌造影增强在区域基础上的总体一致性为 83%，而室壁运动的一致性为 72%。 结论 脉冲反转多普勒成像可以在负荷超声心动图期间实时检测心肌灌注异常，并将进一步提高该测试的质量和灵敏度。 (J Atn Coil Cardiol 2001；37:748-53) (C) 2001 年，美国心脏病学会。
OBJECTIVES We sought to determine how successful pulse inversion Doppler (PID) imaging Would be in detecting myocardial perfusion defects during dobutamine stress echocardiography.BACKGROUND By transmitting multiple pulses of alternating polarity (PID) at a low mechanical index, myocardial contrast enhancement from intravenously injected microbubbles can be detected using real-time frame rates.METHODS Pulse inversion Doppler imaging was performed in 117 patients during dobutamine stress echocardiography by using an intravenous bolus of a perfluorocarbon-filled, albumin-Optison: n = 98) or Liposome- (Definity: n = 19) encapsulated microbubble and a mechanical index of 50%.RESULTS There was a virtual absence of signal from the myocardium before contrast injections in all patients. Bright myocardial opacification at peak stress was observed in at least one coronary artery territory at frame rates up to 25 Hz in 114 of the 117 patients during dobutamine stress echocardiography. Regional myocardial contrast defects at peak stress were observed in all 30 patients with >50% stenosis in at least one vessel (13 with single-vessel and 17 with multivessel disease). Contrast defects were observed in 17 territories subtended by >50% diameter stenosis that had normal wall motion at peak stress. Overall agreement between QA and myocardial contrast enhancement on a territorial basis was 83%, as compared with 72% for wall motion.CONCLUSIONS Pulse inversion Doppler imaging allows the detection of myocardial perfusion abnormalities in real-time during stress echocardiography and will further add to the quality and sensitivity of this test. (J Atn Coil Cardiol 2001;37:748-53) (C) 2001 by the American College of Cardiology.