Simulation System for Multiscale Biological Function Models that Require Complex Calculation Scheme
Simulation System for Multiscale Biological Function Models that Require Complex Calculation Scheme
复制标题
需要复杂计算方案的多尺度生物功能模型仿真系统
DOI：
10.11239/jsmbe.53.115
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发表时间：
2015
影响因子：
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通讯作者：
天野 晃，プンザラン フローレンシオ ラスティ，嶋吉 隆夫，國枝 義敏
中科院分区：
文献类型：
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作者：
Takao Shimayoshi;Chae Young Cha;Akira Amano;姫野友紀子，天野晃，野間昭典;天野 晃，プンザラン フローレンシオ ラスティ，嶋吉 隆夫，國枝 義敏
许多生物学发现在生命科学领域不断被报道。大多数是关于某些蛋白质之间的相关性，或者某些蛋白质与全身血流动力学等宏观现象之间的相关性的报道。为了理解生物系统的潜在机制，多尺度生物功能模型的模拟和分析被认为是有用的。由于有效地计算这些模型需要复杂的计算方案，因此用计算机程序可读的描述性语言来表示生物功能模型和计算方案是有用的。在本报告中，我们介绍了我们的模拟系统，该系统根据由描述语言描述的生物功能模型和计算方案生成模拟程序。使用我们的系统，我们能够生成心室肌细胞模型和全身循环模型耦合的血流动力学模拟模型、评估给药后心室肌细胞模型动作电位变化的模拟程序以及通过改变特定参数计算心室肌细胞动作电位变化的程序。
Many biological findings are continuously reported in the life science area. Most of them are reports on the correlations between some proteins, or correlations between some proteins and macroscopic phenomena such as whole body hemodynamics. In order to understand the underlying mechanisms of the biological systems, simulation and analysis of multiscale biological function models are considered useful. Since the complex calculation schemes are necessary to calculate these models efficiently, it is useful to represent both the biological function models and the calculation schemes in descriptive languages which are readable by the computer programs. In this report, we introduce our simulation system which generates simulation programs from biological function models and calculation schemes both described by description languages. Using our system, we were able to generate simulation programs for a hemodynamic simulation model coupling a ventricular myocyte model and a whole body circulation model, a simulation model that evaluates the changes in action potential of a ventricular myocyte model after drug administration, and a program that calculates the changes in action potential of ventricular myocytes by changing specific parameters.