Distinct functions of ventral CA1 and dorsal CA2 in social memory
Distinct functions of ventral CA1 and dorsal CA2 in social memory
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DOI：
10.1016/j.conb.2020.12.008
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发表时间：
2021-01
影响因子：
5.7
通讯作者：
Akiyuki Watarai;Kentaro Tao;Mu-Yun Wang;T. Okuyama
中科院分区：
文献类型：
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作者：
Akiyuki Watarai;Kentaro Tao;Mu-Yun Wang;T. Okuyama
审查的目的对于生活在社会群体中的动物，识别同种的能力是必不可少的。最近对人类患者和动物模型的研究都在积极地寻求辨别海马神经元和神经回路对社会记忆的编码、巩固、储存和检索做出贡献的精确机制。特别是，光遗传学操作使我们能够研究记忆痕迹的存在。最近的发现我们最近揭示了社会记忆痕迹的存在，海马腹侧CA1神经元，使用光遗传学操作和钙（Ca 2+）成像。总结在本手稿中，我们讨论了目前的观点，两个海马亚区方面的社会记忆表征，即背侧CA2用于信息处理，腹侧CA1用于社会记忆的存储，特别是从行为神经科学和神经生理学的角度来看。
Purpose of reviewFor animals that live in social groups, the ability to recognize conspecifics is essential. Recent studies of both human patients and animal models have vigorously sought to discern the precise mechanisms by which hippocampal neurons and neural circuits contribute to the encoding, consolidation, storage, and retrieval of social memory. In particular, optogenetic manipulation enables us to investigate the presence of memory engrams.Recent findingsWe recently revealed the presence of social memory engrams in hippocampal ventral CA1 neurons, using optogenetic manipulation and calcium (Ca2+) imaging.SummaryIn the present manuscript, we discuss the current viewpoints on two hippocampal subregions in regards to social memory representation, namely dorsal CA2 for information processing and ventral CA1 for the storage of social memory, specifically from the perspectives of behavioral neuroscience and neurophysiology.